Name | alverine citrate |
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Synonyms |
N-ethyl-3-phenyl-N-(3-phenylpropyl)propan-1-amine,2-hydroxypropane-1,2,3-tricarboxylic acid
MFCD00035086 EINECS 226-929-3 Alverine Citrate Alverine (citrate) |
Description | Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM. |
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Related Catalog | |
Target |
5-HT1A Receptor:101 nM (IC50) |
In Vitro | Alverine is a drug used for functional gastrointestinal disorders. Alverine acts directly on the muscle in the gut, causing it to relax. Alverine Citrate (20 mg/kg) suppresses the effect of 5-HTP, but not that of 8-OH-DPAT. However, when injected intracerebroventricularly (75 μg/rat) alverine citrate reduces 8-OH-DPAT-induced enhancement of rectal distension-induced abdominal contractions. In-vitro binding studies reveal that Alverine citrate has a high affinity for 5-HT1A receptors and a weak affinity for 5-HT3 and 5-HT4 subtypes[1]. Alverine may increase Ca influx during action potentials due to inhibition of the inactivation of L-type Ca channels, but may also suppress evoked activity by inhibiting the sensitivity of contractile proteins to Ca2+[2]. |
References |
Boiling Point | 358.8ºC at 760mmHg |
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Molecular Formula | C26H35NO7 |
Molecular Weight | 473.55900 |
Flash Point | 174.4ºC |
Exact Mass | 473.24100 |
PSA | 135.37000 |
LogP | 3.32540 |
Storage condition | -20°C |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
HS Code | 2921499090 |
HS Code | 2921499090 |
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Summary | 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |