162408-66-4

162408-66-4 structure

Name: GR 103691
Chemical Name: 4-(4-acetylphenyl)-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide
CAS Number: 162408-66-4
Molecular Formula: C₃₀H₃₅N₃O₃
Molecular Weight: 485.617
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-12-18 05:10:31
Modify Date: 2024-01-30 19:24:56
GR 103691 is a potent, selective dopamine D3 receptor antagonist with a Ki value of 0.4 nM. GR 103691 shows more than 100-fold selectivity for human dopamine human (h)D3 over hD4 and hD1 sites[1].

Name	4-(4-acetylphenyl)-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide
Synonyms	4'-Acetyl-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}biphenyl-4-carboxamide 4'-Acetyl-N-{4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl}-4-biphenylcarboxamide Tocris-1109 [1,1'-Biphenyl]-4-carboxamide, 4'-acetyl-N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]- MFCD00936840

Description	GR 103691 is a potent, selective dopamine D3 receptor antagonist with a Ki value of 0.4 nM. GR 103691 shows more than 100-fold selectivity for human dopamine human (h)D3 over hD4 and hD1 sites[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	Ki: 0.4 nM (Human dopamine D3 receptor)[1]
In Vitro	GR 103691 shows marked affinity for serotonin1A (5-HT1A) receptors (Ki of 5.8 nM) and α-1 adrenoceptors (Ki of 12.6 nM)[1].
References	[1]. Audinot V, et al. A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J Pharmacol Exp Ther. 1998 Oct;287(1):187-97.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport