70006-24-5

70006-24-5 structure

Name: ABT-724
Chemical Name: ABT 724 trihydrochloride,2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazoletrihydrochloride
CAS Number: 70006-24-5
Molecular Formula: C₁₇H₁₉N₅
Molecular Weight: 293.36600
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-11-23 12:29:39
Modify Date: 2024-01-27 00:43:59
ABT-724 is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM). ABT-724 has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile[1].

Name	ABT 724 trihydrochloride,2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazoletrihydrochloride
Synonyms	abt 724 trihydrochloride abt 724

Description	ABT-724 is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM). ABT-724 has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	EC50: 12.4 nM (Human dopamine D4 receptor), 14.3 nM (Rat dopamine D4 receptor) and 23.2 nM (Ferret dopamine D4 receptor)[1]
In Vitro	ABT-724 exhibits a selective biochemical profile, as indicates by a lack of binding affinity for >70 neurotransmitter/uptake/ion channels including D2, D3, or D5 receptors up to a 10 μM concentration. A weak affinity to 5-HT1A receptors (Ki = 2780 nM) is observed. ABT-724 does not inhibit the PDE activity of PDE1, PDE5, or PDE6 at 10 μM concentrations[1].
In Vivo	ABT-724 (8.8 μg/kg; subcutaneous injection; daily; for 5 days; male adult Wistar rats) treatment dose-dependently facilitates penile erection when given s.c. to conscious rats[1]. Animal Model: Male adult Wistar rats (~300 g)[1] Dosage: 8.8 μg/kg Administration: Subcutaneous injection; daily; for 5 days Result: Dose-dependently facilitated penile erection.
References	[1]. Brioni JD, et al. Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6758-63.

Density	1.275g/cm3
Boiling Point	548.6ºC at 760 mmHg
Molecular Formula	C₁₇H₁₉N₅
Molecular Weight	293.36600
Flash Point	285.6ºC
Exact Mass	293.16400
PSA	48.05000
LogP	2.28300
Index of Refraction	1.687

Hazard Codes	Xi

34803-66-2

~70%

70006-24-5

Literature: Cowart, Marlon D.; Bhatia, Pramila A.; Daanen, Jerome F.; Stewart, Andrew O.; Patel, Meena V.; Kolasa, Teodozyj; Brioni, Jorge D.; Rohde, Jeffrey Patent: US2002/169166 A1, 2002 ;

4857-04-9

34803-66-2

~74%

70006-24-5

Literature: Cowart, Marlon; Latshaw, Steven P.; Bhatia, Pramila; Daanen, Jerome F.; Rohde, Jeffrey; Nelson, Sherry L.; Patel, Meena; Kolasa, Teodozyi; Nakane, Masaki; Uchic, Marie E.; Miller, Loan N.; Terranova, Marc A.; Chang, Renjie; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Hollingsworth, Peter R.; Martino, Brenda R.; Lynch III, James J.; Sullivan, James P.; Hsieh, Gin C.; Moreland, Robert B.; Brioni, Jorge D.; Stewart, Andrew O. Journal of Medicinal Chemistry, 2004 , vol. 47, # 15 p. 3853 - 3864

Precursor 2
34803-66-2 4857-04-9
DownStream 0

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