118025-43-7

118025-43-7 structure

Name: PHM-27 (human)
Chemical Name: PHM 27 (human)
CAS Number: 118025-43-7
Molecular Formula: C₁₃₅H₂₁₄N₃₄O₄₀S
Molecular Weight: 2985.41000
Catalog: Signaling Pathways GPCR/G Protein CGRP Receptor
Create Date: 2016-12-19 03:00:48
Modify Date: 2024-01-06 11:47:38
PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC50 of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism[1][2][3].

Name	PHM 27 (human)
Synonyms	phm,human h-his-ala-asp-gly-val-phe-thr-ser-asp-phe-ser-lys-leu-leu-gly-gln-leu-ser-ala-lys-lys-tyr-leu-glu-ser-leu-met-nh2 peptide histidine methionine,human his-ala-asp-gly-val-phe-thr-ser-asp-phe-ser-lys-leu-leu-gly-gln-leu-ser-ala-lys-lys-tyr-leu-glu-ser-leu-met-nh2 m.w. 2985.41 c135h214n34o40s

Description	PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC50 of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CGRP Receptor Research Areas >> Cardiovascular Disease Signaling Pathways >> Neuronal Signaling >> CGRP Receptor Research Areas >> Metabolic Disease
Target	EC50: 11 nM (human calcitonin receptor)[2]
References	[1]. N Itoh, et al. Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature. 1983 Aug 11-17;304(5926):547-9. [2]. Jian-Nong Ma, et al. Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor. Biochem Pharmacol. 2004 Apr 1;67(7):1279-84. [3]. I Kato, et al. Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic beta cells. Evidence for improved glucose tolerance and enhanced insulin secretion by VIP and PHM-27 in vivo. J Biol Chem. 1994 Aug 19;269(33):21223-8.