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141992-47-4

141992-47-4 structure
141992-47-4 structure
  • Name: NSC 625987
  • Chemical Name: 1,4-dimethoxy-10H-acridine-9-thione
  • CAS Number: 141992-47-4
  • Molecular Formula: C15H13NO2S
  • Molecular Weight: 271.33400
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
  • Create Date: 2018-12-04 20:13:49
  • Modify Date: 2024-01-14 19:02:29
  • NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2[1].

Name 1,4-dimethoxy-10H-acridine-9-thione
Synonyms 1,4-Dimethoxy-9-thio(10H)-acridone
Tocris-2152
Description NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2[1].
Related Catalog
Target

CDK4/D1:0.2 μM (IC50)

In Vitro NSC 625987 (10 nM, 50 nM, 100 nM) treatment attenuates the enhanced proliferation of vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) rats by about 35%[2].
References

[1]. A Kubo, et al. The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin Cancer Res. 1999 Dec;5(12):4279-86.

[2]. Jasmine El Andalousi, et al.Natriuretic peptide receptor-C agonist attenuates the expression of cell cycle proteins and proliferation of vascular smooth muscle cells from spontaneously hypertensive rats: role of Gi proteins and MAPkinase/PI3kinase signaling. PLoS One. 2013 Oct 14;8(10):e76183.

Density 1.32g/cm3
Boiling Point 460.4ºC at 760 mmHg
Molecular Formula C15H13NO2S
Molecular Weight 271.33400
Flash Point 232.2ºC
Exact Mass 271.06700
PSA 66.34000
LogP 4.06780
Vapour Pressure 1.17E-08mmHg at 25°C
Index of Refraction 1.683