NSC 625987

Modify Date: 2024-01-14 19:02:29

NSC 625987 structure	Common Name	NSC 625987
	CAS Number	141992-47-4	Molecular Weight	271.33400
	Density	1.32g/cm3	Boiling Point	460.4ºC at 760 mmHg
	Molecular Formula	C₁₅H₁₃NO₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	232.2ºC

Use of NSC 625987

NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2[1].

Name	1,4-dimethoxy-10H-acridine-9-thione
Synonym	More Synonyms

Description	NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK4/D1:0.2 μM (IC50)
In Vitro	NSC 625987 (10 nM, 50 nM, 100 nM) treatment attenuates the enhanced proliferation of vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) rats by about 35%[2].
References	[1]. A Kubo, et al. The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin Cancer Res. 1999 Dec;5(12):4279-86. [2]. Jasmine El Andalousi, et al.Natriuretic peptide receptor-C agonist attenuates the expression of cell cycle proteins and proliferation of vascular smooth muscle cells from spontaneously hypertensive rats: role of Gi proteins and MAPkinase/PI3kinase signaling. PLoS One. 2013 Oct 14;8(10):e76183.

Density	1.32g/cm3
Boiling Point	460.4ºC at 760 mmHg
Molecular Formula	C₁₅H₁₃NO₂S
Molecular Weight	271.33400
Flash Point	232.2ºC
Exact Mass	271.06700
PSA	66.34000
LogP	4.06780
Vapour Pressure	1.17E-08mmHg at 25°C
Index of Refraction	1.683

NSC 625987 MSDS(Chinese)

1,4-Dimethoxy-9...

CAS#:25379-15-1

~84%

NSC 625987

CAS#:141992-47-4

Literature: Arzneimittel-Forschung/Drug Research, , vol. 42, # 5 p. 674 - 679

2-[(2,5-dimetho...

CAS#:21193-37-3

NSC 625987

CAS#:141992-47-4

Literature: Annales Pharmaceutiques Francaises, , vol. 54, # 1 p. 27 - 33

2,5-Dimethoxyaniline

CAS#:102-56-7

NSC 625987

CAS#:141992-47-4

Literature: Annales Pharmaceutiques Francaises, , vol. 54, # 1 p. 27 - 33

2-Chlorobenzoic acid

CAS#:118-91-2

NSC 625987

CAS#:141992-47-4

Literature: Annales Pharmaceutiques Francaises, , vol. 54, # 1 p. 27 - 33

Precursor 4
CAS#:25379-15-1 1,4-Dimethoxy-9... CAS#:21193-37-3 2-[(2,5-dimetho... CAS#:102-56-7 2,5-Dimethoxyaniline CAS#:118-91-2 2-Chlorobenzoic acid
DownStream 2
CAS#:141992-48-5 9-ethylsulfanyl... CAS#:141992-60-1 1-[4-(hydroxyme...