107430-66-0

107430-66-0 structure

Name: CD 1530
Chemical Name: 4-[7-(1-adamantyl)-6-hydroxynaphthalen-2-yl]benzoic acid
CAS Number: 107430-66-0
Molecular Formula: C₂₇H₂₆O₃
Molecular Weight: 398.49400
Catalog: Signaling Pathways Metabolic Enzyme/Protease RAR/RXR
Create Date: 2017-06-30 06:47:22
Modify Date: 2024-01-07 19:14:13
CD1530 is a selective RARγ agonist with an Kd of 150 nM[1]. CD1530 has been used in combination with bexarotene to inhibit oral carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide in a mouse model of human oral-cavity and esophageal squamous-cell carcinoma[2].

Name	4-[7-(1-adamantyl)-6-hydroxynaphthalen-2-yl]benzoic acid
Synonyms	cd 1530

Description	CD1530 is a selective RARγ agonist with an Kd of 150 nM[1]. CD1530 has been used in combination with bexarotene to inhibit oral carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide in a mouse model of human oral-cavity and esophageal squamous-cell carcinoma[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR
Target	RARγ:150 nM (Kd)
References	[1]. Bernard BA, et al. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun. 1992 Jul 31;186(2):977-83. [2]. Tang XH, et al. Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8907-12.