170663-33-9

170663-33-9 structure

Name: α-Conotoxin EI
Chemical Name: α-Conotoxin EI
CAS Number: 170663-33-9
Molecular Formula: C₈₃H₁₂₅N₂₇O₂₇S₅
Molecular Weight: 2093.37000
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2018-12-26 15:03:04
Modify Date: 2024-01-12 12:16:20
α-Conotoxin EI is a selective nicotinic acetylcholine α1β1γδ receptor (nAChR) antagonist (IC50=187 nM) and an α3β4 receptor inhibitor. α-Conotoxin EI can block muscle and ganglionic receptors[1][2][3].

Name	α-Conotoxin EI
Synonyms	ARG-ASP-HYP-CYS-CYS-TYR-HIS-PRO-THR-CYS-ASN-MET-SER-ASN-PRO-GLN-ILE-CYS-NH2 A-CONOTOXIN EL ARG-ASP-HYP-CYS-CYS-TYR-HIS-PRO-THR-CYS-ASN-MET-SER-ASN-PRO-GLN-ILE-CYS RDHYPCCYHPTCNMSNPQIC-NH2 H-ARG-ASP-HYP-CYS-CYS-TYR-HIS-PRO-THR-CYS-ASN-MET-SER-ASN-PRO-GLN-ILE-CYS-NH2 a-Conotoxin El,Conus ermineus

Description	α-Conotoxin EI is a selective nicotinic acetylcholine α1β1γδ receptor (nAChR) antagonist (IC50=187 nM) and an α3β4 receptor inhibitor. α-Conotoxin EI can block muscle and ganglionic receptors[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
Target	IC50: 187 nM (nicotinic acetylcholine α1β1γδ receptor)[3]
In Vitro	α-Conotoxin EI (10 µM) blocks muscle and ganglionic receptors, but less potent for the central nevous system receptor[3]. α-Conotoxin EI (10 µM) blocks the α1β1γδ receptors with a τon of 4.9 s, and blocks the α3β4 receptor with a τon of 11 s[3].
In Vivo	α-Conotoxin EI (intraperitoneal injection) into mice induces muscular weakness, followed by flaccid paralysis and ultimately death[1].