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187947-37-1

187947-37-1 structure
187947-37-1 structure
  • Name: Arachidonoyl serotonin
  • Chemical Name: Arachidonoylserotonin
  • CAS Number: 187947-37-1
  • Molecular Formula: C30H42N2O2
  • Molecular Weight: 462.667
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
  • Create Date: 2016-02-18 18:39:08
  • Modify Date: 2025-08-22 15:30:54
  • N-Arachidonoylserotonin (Arachidonyl serotonin; AA-5-HT) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 value of 1~12 µM. N-Arachidonoylserotonin acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels (IC50=70~100 nM). N-Arachidonoylserotonin is analgesic in rodents [1].
Name Arachidonoylserotonin
Synonyms (5Z,8Z,11Z,14Z)-N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-icosatetraenamide
Arachidonoyl serotonin
AA-5-HT N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenamide
(5Z,8Z,11Z,14Z)-N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]icosa-5,8,11,14-tetraenamide
Arachidonyl serotonin,N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide
5,8,11,14-Eicosatetraenamide, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-, (5Z,8Z,11Z,14Z)-
Arachidonyl serotonin
N-Arachidonoylserotonin
Description N-Arachidonoylserotonin (Arachidonyl serotonin; AA-5-HT) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 value of 1~12 µM. N-Arachidonoylserotonin acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels (IC50=70~100 nM). N-Arachidonoylserotonin is analgesic in rodents [1].
Related Catalog
Target

IC50: 1~12 µM (FAAH), 70~100 nM (TRPV1 channels)[1]

References

[1]. Ortar G, et al. New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. J Med Chem. 2007;50(26):6554-6569.
Density 1.0±0.1 g/cm3
Boiling Point 680.5±55.0 °C at 760 mmHg
Molecular Formula C30H42N2O2
Molecular Weight 462.667
Flash Point 365.3±31.5 °C
Exact Mass 462.324615
PSA 65.12000
LogP 7.16
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.574
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
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title: CAS No. 187947-37-1 | Chemsrc address: https://m.chemsrc.com/en/baike/1195310.html

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