Name | dicloxacillin |
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Synonyms |
Dicloxacillin
Pathocil (2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (2S,5R,6R)-6-({[3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid dicluxacillin (2S,5R,6R)-6-[[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid EINECS 221-488-3 Dicloxacycline Dynapen 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)- Dicloxacilina Maclicine MFCD00210902 Dicloxacilin Dycill (2S-(2a,5a,6b))-6-(((3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Dicloxacillinum (2S,5R,6R)-6-(((3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid |
Description | Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus[1]. |
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Related Catalog | |
In Vitro | Dicloxacillin exhibits EC50 values of 0.06 and 0.50 mg/L in ATCC 25923 and E19977, respectively. Dicloxacillin exhibits MIC values of 0.125 and 0.5 mg/L in ATCC 25923 and E19977 with pH 7.4, respectively[2]. |
In Vivo | Dicloxacillin exhibits therapeutic activity in murine peritonitis-sepsis model and all the mice are survivied[3]. Animal Model: Female outbred Swiss Webster mice (Murine peritonitis-sepsis model)[3]. Dosage: 125 mg/kg. Administration: IV injection, single doses. Result: All the mice survived. |
References |
Density | 1.6±0.1 g/cm3 |
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Boiling Point | 692.4±55.0 °C at 760 mmHg |
Molecular Formula | C19H17Cl2N3O5S |
Molecular Weight | 470.326 |
Flash Point | 372.5±31.5 °C |
Exact Mass | 469.026581 |
PSA | 138.04000 |
LogP | 3.02 |
Vapour Pressure | 0.0±2.3 mmHg at 25°C |
Index of Refraction | 1.691 |
Water Solubility | 3.63 mg/L |