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7558-79-4

7558-79-4 structure
7558-79-4 structure
  • Name: Disodium hydrogenorthophosphate
  • Chemical Name: disodium hydrogenphosphate
  • CAS Number: 7558-79-4
  • Molecular Formula: HNa2O4P
  • Molecular Weight: 141.96
  • Catalog: Inorganic chemical industry Inorganic salt Phosphides, metal phosphoric acid, metaphosphoric acid, hypophosphorous acid and pyrophosphate
  • Create Date: 2018-02-08 08:00:00
  • Modify Date: 2024-01-02 18:45:55
  • Disodium phosphate is also known as Na2HPO4 to adjust pH of liquid. Disodium phosphate can be used as an excipient, such as buffer, chelating agent. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

Name disodium hydrogenphosphate
Synonyms Disodium hydrogenorthophosphate
EINECS 231-448-7
disodium,hydrogen phosphate
MFCD00003496
Description Disodium phosphate is also known as Na2HPO4 to adjust pH of liquid. Disodium phosphate can be used as an excipient, such as buffer, chelating agent. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Related Catalog
References

[1]. Baldus M, et al. Structure investigation on anhydrous disodium hydrogen phosphate using solid-state NMR and X-ray techniques[J]. Journal of the American Chemical Society, 1995, 117(18): 5141-5147.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

Density 1.064 g/mL at 20 °C
Boiling Point 158ºC at 760 mmHg
Melting Point 243-245 °C
Molecular Formula HNa2O4P
Molecular Weight 141.96
Exact Mass 141.940781
PSA 93.23000
Vapour density 4.9 (vs air)
Storage condition Store at RT.
Stability Stable. Incompatible with strong acids. Hygroscopic.
Water Solubility >=10 g/100 mL at 20 ºC

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WC4500000
CAS REGISTRY NUMBER :
7558-79-4
LAST UPDATED :
199701
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
H-O4-P.2Na
MOLECULAR WEIGHT :
141.96
WISWESSER LINE NOTATION :
NA2 P-O-Q3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,16,1972
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,16,1972 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
17 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,16,1972
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIZEA2 Biochemische Zeitschrift. (Berlin, Ger.) V.1-346, 1906-67. For publisher information, see EJBCAI. Volume(issue)/page/year: 163,226,1925
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIZEA2 Biochemische Zeitschrift. (Berlin, Ger.) V.1-346, 1906-67. For publisher information, see EJBCAI. Volume(issue)/page/year: 163,226,1925
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIZEA2 Biochemische Zeitschrift. (Berlin, Ger.) V.1-346, 1906-67. For publisher information, see EJBCAI. Volume(issue)/page/year: 163,226,1925
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1075 mg/kg
TOXIC EFFECTS :
Behavioral - tetany
REFERENCE :
HXPHAU Handbuch der Experimentellen Pharmakologie. (Berlin, Ger.) New series: V.1-49, 1935-78. For publisher information, see HEPHD2. Volume(issue)/page/year: 10,361,1950 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83514 No. of Facilities: 6564 (estimated) No. of Industries: 85 No. of Occupations: 60 No. of Employees: 57176 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83514 No. of Facilities: 21015 (estimated) No. of Industries: 166 No. of Occupations: 135 No. of Employees: 1230592 (estimated) No. of Female Employees: 912048 (estimated)
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36-S24/25
RIDADR UN 3077 9 / PGIII
WGK Germany 3
RTECS WC4500000
HS Code 2835220000
HS Code 2835220000