151126-32-8

151126-32-8 structure

Name: Pramlintide
Chemical Name: Pramlintide
CAS Number: 151126-32-8
Molecular Formula: C₁₇₁H₂₆₉N₅₁O₅₃S₂
Molecular Weight: 3949.43
Catalog: Research Areas Metabolic Disease
Create Date: 2018-07-04 18:28:41
Modify Date: 2024-01-04 11:22:17
Pramlintide is a polypeptide analogue of human amylin. Pramlintide is an antidiabetic, is antineoplastic in colorectal cancer[1].

Name	Pramlintide
Synonyms	Triproamylin

Description	Pramlintide is a polypeptide analogue of human amylin. Pramlintide is an antidiabetic, is antineoplastic in colorectal cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	Pramlintide inhibits the growth of HCT-116 and HT-29 in a dose-dependent manner, with higher efficacy against the latter (IC50s of 48.67 and 9.10 μg/mL, respectively)[1]. The addition of 5, 10, and 20 μg/mL of Pramlintide to HCT-116 and HT-29 with 5-fluorouracil, Oxaliplatin, or Irinotecan induces the antiproliferative effect synergistically[1].
References	[1]. Maha S Al-Keilani, et al. Pramlintide, an antidiabetic, is antineoplastic in colorectal cancer and synergizes with conventional chemotherapy. Clin Pharmacol. 2018 Mar 5;10:23-29.