Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Biotin alkyne
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

DC Chemicals Limited
China
Product Name: Biotin alkyne
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-2-oxo-N-2-propynyl-, (3aS,4S,6aR)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

773888-45-2

773888-45-2 structure

773888-45-2 structure

Name: Biotin alkyne
Chemical Name: N-(Prop-2-ynyl)biotinamide
CAS Number: 773888-45-2
Molecular Formula: C₁₃H₁₉N₃O₂S
Molecular Weight: 281.37400
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-05-12 08:00:00
Modify Date: 2024-01-09 22:46:42
Biotin alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	N-(Prop-2-ynyl)biotinamide
Synonyms	Biotin propargylamide, 3-(D-Biotinylamido)-1-propyne, Prop-2-ynylamide biotin 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(prop-2-ynyl)pentanamide

Description	Biotin alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014.

Density	1.185±0.06 g/cm3(Predicted)
Boiling Point	614.8±50.0 °C(Predicted)
Melting Point	169-170 °C
Molecular Formula	C₁₃H₁₉N₃O₂S
Molecular Weight	281.37400
Exact Mass	281.12000
PSA	95.53000
LogP	1.51010

Hazard Codes	Xi