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773888-45-2

773888-45-2 structure
773888-45-2 structure
  • Name: Biotin alkyne
  • Chemical Name: N-(Prop-2-ynyl)biotinamide
  • CAS Number: 773888-45-2
  • Molecular Formula: C13H19N3O2S
  • Molecular Weight: 281.37400
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-05-12 08:00:00
  • Modify Date: 2024-01-09 22:46:42
  • Biotin alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name N-(Prop-2-ynyl)biotinamide
Synonyms Biotin propargylamide, 3-(D-Biotinylamido)-1-propyne, Prop-2-ynylamide biotin
5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(prop-2-ynyl)pentanamide
Description Biotin alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014.

Density 1.185±0.06 g/cm3(Predicted)
Boiling Point 614.8±50.0 °C(Predicted)
Melting Point 169-170 °C
Molecular Formula C13H19N3O2S
Molecular Weight 281.37400
Exact Mass 281.12000
PSA 95.53000
LogP 1.51010
Hazard Codes Xi