957230-65-8
957230-65-8 structure
- Name: Isofagomine D-Tartrate
- Chemical Name: Afegostat
- CAS Number: 957230-65-8
- Molecular Formula: C10H19NO9
- Molecular Weight: 297.26
- Catalog: Research Areas Neurological Disease
- Create Date: 2018-12-19 00:29:49
- Modify Date: 2024-01-04 21:07:11
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Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1].
| Name | Afegostat |
|---|---|
| Synonyms |
Isofagomine D-Tartrate
Butanedioic acid, 2,3-dihydroxy-, (2S,3S)-, compd. with (3R,4R,5R)-5-(hydroxymethyl)-3,4-piperidinediol (1:1) (2S,3S)-2,3-Dihydroxysuccinic acid - (3R,4R,5R)-5-(hydroxymethyl)-3,4-piperidinediol (1:1) (3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol (2S,3S)-2,3-Dihydroxybutanedioate Afegostat (D-Tartrate) |
| Description | Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1]. |
|---|---|
| Related Catalog | |
| Target |
GCase[1] |
| In Vivo | Vivo: Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates[1]. |
| References |
| Molecular Formula | C10H19NO9 |
|---|---|
| Molecular Weight | 297.26 |
| Exact Mass | 297.105988 |
| Storage condition | 2-8℃ |