957230-65-8

957230-65-8 structure

Name: Isofagomine D-Tartrate
Chemical Name: Afegostat
CAS Number: 957230-65-8
Molecular Formula: C₁₀H₁₉NO₉
Molecular Weight: 297.26
Catalog: Research Areas Neurological Disease
Create Date: 2018-12-19 00:29:49
Modify Date: 2024-01-04 21:07:11
Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1].

Name	Afegostat
Synonyms	Isofagomine D-Tartrate Butanedioic acid, 2,3-dihydroxy-, (2S,3S)-, compd. with (3R,4R,5R)-5-(hydroxymethyl)-3,4-piperidinediol (1:1) (2S,3S)-2,3-Dihydroxysuccinic acid - (3R,4R,5R)-5-(hydroxymethyl)-3,4-piperidinediol (1:1) (3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol (2S,3S)-2,3-Dihydroxybutanedioate Afegostat (D-Tartrate)

Description	Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	GCase[1]
In Vivo	Vivo: Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates[1].
References	[1]. Richter F, et al. A GCase chaperone improves motor function in a mouse model of synucleinopathy. Neurotherapeutics. 2014 Oct;11(4):840-56.