1137359-47-7

1137359-47-7 structure

Name: BRD7552
Chemical Name: brd7552
CAS Number: 1137359-47-7
Molecular Formula: C₃₃H₃₃N₃O₁₅
Molecular Weight: 711.626
Catalog: Research Areas Endocrinology
Create Date: 2016-01-28 14:00:36
Modify Date: 2025-08-25 10:45:30
BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression.Target: PDX1 [1]in vitro: BRD7552 upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases PDX1 mRNA levels by 2- to 4-fold, with a maximal effect at 5 μM and the expression of MAFA. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. Treatment of PANC-1 cells with BRD7552 causes a dose-dependent increase in insulin mRNA expression. [1]

Name	brd7552
Synonyms	α-D-Glucopyranoside, methyl, 2,3-bis(1,3-benzodioxol-5-ylcarbamate) 4-[[4-(ethoxycarbonyl)phenyl]carbamate] Methyl 2,3-bis-O-(1,3-benzodioxol-5-ylcarbamoyl)-4-O-{[4-(ethoxycarbonyl)phenyl]carbamoyl}-α-D-glucopyranoside

Description	BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression.Target: PDX1 [1]in vitro: BRD7552 upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases PDX1 mRNA levels by 2- to 4-fold, with a maximal effect at 5 μM and the expression of MAFA. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. Treatment of PANC-1 cells with BRD7552 causes a dose-dependent increase in insulin mRNA expression. [1]
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Endocrinology
References	[1]. Yuan Y, et al. A small-molecule inducer of PDX1 expression identified by high-throughput screening. Chem Biol. 2013 Dec 19;20(12):1513-1522.

RIDADR	NONH for all modes of transport