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9045-22-1

9045-22-1 structure
9045-22-1 structure
  • Name: Heparin lithium salt
  • Chemical Name: Heparin lithium salt
  • CAS Number: 9045-22-1
  • Molecular Formula: (C14H25NO20S3)n.xLi
  • Molecular Weight: 148.159
  • Catalog: Biochemical Carbohydrate Polysaccharide
  • Create Date: 2018-08-28 17:29:07
  • Modify Date: 2024-01-04 08:29:31
  • Heparin Lithium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII).
Name Heparin lithium salt
Synonyms (E)-3-Phenylprop-2-enoic acid
Propenoic acid, 3-phenyl-, (trans)-
MFCD00131308
Cinnamic acid
(2E)-3-Phenylacrylic acid
trans-Cinnamic Acid
QV1U1R &&Trans or E Form
2-Propenoic acid, 3-phenyl-, (2E)-
4-09-00-02002 (Beilstein Handbook Reference)
trans-b-Carboxystyrene
Description Heparin Lithium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII).
Related Catalog
Target

Antithrombin III[1]

In Vitro Heparin is a potent anticoagulant drug based on its ability to accelerate the rate at which antithrombin inhibits serine proteases in the blood coagulation cascade. Heparin interactes most tightly with peptides containing a complementary binding site of high positive charge density. Heparin resembles DNA as both are highly charged linear polymers that behave as polyelectrolytes. Heparin is believed to function as an anticoagulant primarily through its interaction with AT III by enhancing AT-III-mediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin binds to AT III and thrombin in a ternary complex, increasing the bimolecular rate constant for the inhibition of thrombin by a factor of 2000. Heparin is principally located in the granules of tissue mast cells that are closely associated with the immune response. Heparin makes numerous contacts with both FGF-2 and FGFR-1 stabilizing FGF–FGFR binding. Heparin also makes contacts with the FGFR-1 of the adjacent FGF–FGFR complex, thus seeming to promote FGFR dimerization[1].
References

[1]. Capila I, et al. Heparin-protein interactions. Angew Chem Int Ed Engl. 2002 Feb 1;41(3):391-412.
Density 1.2±0.1 g/cm3
Boiling Point 265.0±0.0 °C at 760 mmHg
Molecular Formula (C14H25NO20S3)n.xLi
Molecular Weight 148.159
Flash Point 189.5±9.6 °C
Exact Mass 148.052429
LogP 2.41
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.616
Storage condition +15C to +30C
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 22-24/25-36-26
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS MI0700000
HS Code 29319090

Chemsrc provides CAS#:9045-22-1 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 9045-22-1 | Chemsrc address: https://m.chemsrc.com/en/baike/1198883.html

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