Top Suppliers:I want be here
Related CAS#:
20977-05-3 73706-57-7
156028-14-7 9051-29-0
100298-22-4 51032-47-4
3618-60-8 67969-73-7
85684-35-1 29158-40-5
1420826-91-0 1420969-57-8
1420797-08-5 1420874-70-9
1420871-65-3 1420955-02-7
1420971-34-1 1420979-81-2
1420849-86-0 1420837-41-7

20977-05-3

20977-05-3 structure
20977-05-3 structure
  • Name: Sodium Aescinate
  • Chemical Name: Escin monosodium salt
  • CAS Number: 20977-05-3
  • Molecular Formula: C54H83NaO23
  • Molecular Weight: 1124.2202
  • Catalog: API Circulatory system medication Other circulatory system medication
  • Create Date: 2018-06-29 14:41:03
  • Modify Date: 2025-08-22 14:25:45
  • Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities[1]. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway[2].
Name Escin monosodium salt
Synonyms 3-methyl-pyridine-2-carbonitrile
3-methyl-2-pyridinecarbonitrile
2-cyano-3-methly pyridine
2-cyano-b-picoline
3-methylpyridine-2-carbonitrile
2-Cyano-3-methylpyridine
(h4tes4)[qr]
akrochem tdec
diethyl-carbamodithioicacitetrakis(anhydrosulfide)withthiotelluricac
Sodium escinate
Description Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities[1]. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway[2].
Related Catalog
In Vitro Sodium aescinate can block signals transiting to downstream molecules AKT, ERK, inhibit the proliferation of breast cancer cell MCF-7 cell apoptosis and induced cell apoptosis by suppressing the activation of SRC[3].
In Vivo Sodium aescinate may effectively controls and improves wound healing in diabetic rats via its anti-inflammatory and antioxidant activities[1]. Sodium aescinate treatment can alleviate the symptom of polycystic ovary syndrome (PCOS) in rat model through regulating the PI3K/Akt/GSK3-β pathway[4].
References

[1]. Zhang Z, et al. The Efficacy of Sodium Aescinate on Cutaneous Wound Healing in Diabetic Rats. Inflammation. 2015 Oct;38(5):1942-8.

[2]. Hou H, et al. CARMA3/NF-κB signaling contributes to tumorigenesis of hepatocellular carcinoma and is inhibited by sodium aescinate. World J Gastroenterol. 2019 Sep 28;25(36):5483-5493.

[3]. Qi SM, et al. Effect of sodium aescinate in inducing human breast cancer MCF-7 cells apoptosis by inhibiting AKT, ERK and upstream signal SRC activity. Zhongguo Zhong Yao Za Zhi. 2015 Aug;40(16):3267-72.

[4]. Chen L, et al. Effect of sodium aescinate treatment on PCOS rat model with insulin resistance. Bratisl Lek Listy. 2017;118(4):223-227.
Molecular Formula C54H83NaO23
Molecular Weight 1124.2202
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Chemsrc provides CAS#:20977-05-3 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 20977-05-3 | Chemsrc address: https://m.chemsrc.com/en/baike/1199072.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved