479200-82-3
479200-82-3 structure
- Name: Amino-PEG11-amine
- Chemical Name: 3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-diamine
- CAS Number: 479200-82-3
- Molecular Formula: C24H52N2O11
- Molecular Weight: 544.677
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2018-09-18 10:41:49
- Modify Date: 2024-01-18 16:07:08
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Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1].
| Name | 3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-diamine |
|---|---|
| Synonyms | 3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-diamine |
| Description | Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 591.2±45.0 °C at 760 mmHg |
| Molecular Formula | C24H52N2O11 |
| Molecular Weight | 544.677 |
| Flash Point | 299.9±22.4 °C |
| Exact Mass | 544.357117 |
| LogP | -4.81 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.468 |
| Storage condition | 2-8°C |