906099-89-6

906099-89-6 structure

Name: Biotin-PEG6-alcohol
Chemical Name: 1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-N-(17-hydroxy-3,6,9,12,15-pentaoxaheptadec-1-yl)-2-oxo-, (3aS,4S,6aR)-
CAS Number: 906099-89-6
Molecular Formula: C₂₂H₄₁N₃O₈S
Molecular Weight: 507.64100
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-11-05 07:47:00
Modify Date: 2024-01-10 12:58:45
Biotin-PEG6-alcohol is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-N-(17-hydroxy-3,6,9,12,15-pentaoxaheptadec-1-yl)-2-oxo-, (3aS,4S,6aR)-
Synonyms	(+)-Biotin-PEG6-OH

Description	Biotin-PEG6-alcohol is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.