Biotin-PEG6-alcohol

Modify Date: 2024-01-10 12:58:45

Biotin-PEG6-alcohol Structure
Biotin-PEG6-alcohol structure
Common Name Biotin-PEG6-alcohol
CAS Number 906099-89-6 Molecular Weight 507.64100
Density 1.176±0.06 g/cm3(20 °C , 760mmHg) Boiling Point 754.3±60.0 °C (760 mmHg)
Molecular Formula C22H41N3O8S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Biotin-PEG6-alcohol


Biotin-PEG6-alcohol is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-N-(17-hydroxy-3,6,9,12,15-pentaoxaheptadec-1-yl)-2-oxo-, (3aS,4S,6aR)-
Synonym More Synonyms

 Biotin-PEG6-alcohol Biological Activity

Description Biotin-PEG6-alcohol is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

 Chemical & Physical Properties

Density 1.176±0.06 g/cm3(20 °C , 760mmHg)
Boiling Point 754.3±60.0 °C (760 mmHg)
Molecular Formula C22H41N3O8S
Molecular Weight 507.64100
Exact Mass 507.26100
PSA 161.91000
LogP 0.95220
Storage condition 2-8°C

 Synonyms

(+)-Biotin-PEG6-OH