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  • DC Chemicals Limited
  • China
  • Product Name: UC-112
  • Price: $Inquiry/25mg $Inquiry/100mg $Inquiry/250mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao


383392-66-3

383392-66-3 structure
383392-66-3 structure
  • Name: UC 112
  • Chemical Name: 5-((benzyloxy)methyl)-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol
  • CAS Number: 383392-66-3
  • Molecular Formula: C22H24N2O2
  • Molecular Weight: 348.43800
  • Catalog: Signaling Pathways Apoptosis IAP
  • Create Date: 2018-06-14 08:50:08
  • Modify Date: 2024-01-07 22:31:09
  • UC-112 is a novel potent IAP(Inhibitor of apoptosis) inhibitor; potently inhibit cell growth in two human melanoma (A375 and M14) and two human prostate (PC-3 and DU145) cancer cell lines(IC50=0.7-3.4 uM).IC50 value: 0.7-3.4 uM (Cell assay) [1]Target: IAP inhibitorin vitro: UC-112 also potently inhibits the growth of P-glycoprotein (P-gp)-overexpressed multidrug-resistant cancer cells, strongly activates caspase-3/7 and caspase-9 activities, and selectively downregulates survivin level at a concentration as low as 1 μM. Coincubation of UC-112 with a known proteasome inhibitor Z-Leu-Leu-Leu-CHO (MG-132) rescued survivin inhibition, consistent with the anticipated mechanism of action for UC-112 [1].in vivo: As a single agent, UC-112 strongly inhibits tumor growth and reduces both X chromosome-linked IAP and survivin levels in an A375 human melanoma xenograft model in vivo [1].

Name 5-((benzyloxy)methyl)-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol
Synonyms uc-112
Description UC-112 is a novel potent IAP(Inhibitor of apoptosis) inhibitor; potently inhibit cell growth in two human melanoma (A375 and M14) and two human prostate (PC-3 and DU145) cancer cell lines(IC50=0.7-3.4 uM).IC50 value: 0.7-3.4 uM (Cell assay) [1]Target: IAP inhibitorin vitro: UC-112 also potently inhibits the growth of P-glycoprotein (P-gp)-overexpressed multidrug-resistant cancer cells, strongly activates caspase-3/7 and caspase-9 activities, and selectively downregulates survivin level at a concentration as low as 1 μM. Coincubation of UC-112 with a known proteasome inhibitor Z-Leu-Leu-Leu-CHO (MG-132) rescued survivin inhibition, consistent with the anticipated mechanism of action for UC-112 [1].in vivo: As a single agent, UC-112 strongly inhibits tumor growth and reduces both X chromosome-linked IAP and survivin levels in an A375 human melanoma xenograft model in vivo [1].
Related Catalog
References

[1]. Wang J, et al. Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors. J Pharmacol Exp Ther. 2014 May;349(2):319-29.

Molecular Formula C22H24N2O2
Molecular Weight 348.43800
Exact Mass 348.18400
PSA 45.59000
LogP 4.19090
Storage condition 2-8℃