7081-44-9
7081-44-9 structure
- Name: Cloxacillin Sodium
- Chemical Name: cloxacillin sodium monohydrate
- CAS Number: 7081-44-9
- Molecular Formula: C19H19ClN3NaO6S
- Molecular Weight: 475.88
- Catalog: API Antibiotics Penicillin
- Create Date: 2018-06-01 08:00:00
- Modify Date: 2026-07-23 19:15:33
-
Cloxacillin sodium monohydrate is a semi-synthetic antibiotic that is a chlorinated derivative of oxacillin.Target: AntibacterialCloxacillin sodium (Cloxacap) is a sodium salt of cloxacillin that is a penicillinase-resistant, acid resistant, semi-synthetic penicillin. Cloxacillin sodium exerts a bactericidal action against susceptible microorganisms during the stage of active multiplication. Cloxacillin sodium acts through the inhibition of biosynthesis of cell wall mucopeptides. Cloxacillin sodium is readily absorbed following i.m. administration and rapidly reaches therapeutically effective blood levels. Serum levels are approximately proportional to dosage. Peak plasma concentrations of 15 ug/ml have been observed 30 minutes after an i.m. injection of cloxacillin (Cloxapen, Cloxacap and Orbenin) 500 mg; plasma concentrations may be doubled by administration of a doubled dose. At the end of a 3-hour i.v. infusion of cloxacillin (Cloxapen, Cloxacap and Orbenin) 250 mg given to normal subjects, its plasma concentrations were 15 ug/ml. After 2 hours, plasma concentrations were 0.6 ug/ml [1].
| Name | cloxacillin sodium monohydrate |
|---|---|
| Synonyms |
thyl-4-isoxazolecboxamido)-3,3-dimethyl-7-oxo-,sodiumsalt,monohydrate
Oxacillin Sodium Monohydrate Impurity E as Sodium Salt Monohydrate Tegopen Cloxacillin monohydrate sodium salt 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, sodium salt, (2S,5R,6R)-, hydrate (1:1:1) Sodium(2S,5R,6R)-6-[[[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylatemonohydrate cloxacillin sodium hydrate Cloxapen Austrastaph [5-METHYL-3-(O-CHLOROPHENYL)-4-ISOXAZOLYL]PENICILLIN SODIUM SALT MONOHYDRATE Cloxacillin (sodium monohydrate) prostaphlin-amonohydrate Cloxacillin hydrate sodium salt Prevencilina P Cloxacillin sodium salt hydrate Claxacillin Sodium(Sodium) Cloxacillin Sodium Salt Monohydrate> Sodium cloxacillin monohydrate CLOXACILLIN SODIUM C(CRM STANDD) CLOXACILLIN SODIUM SALT HYDRATE CLOXACILLIN SODIUM (CRM STANDD) Cloxacillin sodiumQ: What is Cloxacillin sodium Q: What is the CAS Number of Cloxacillin sodium Q: What is the storage condition of Cloxacillin sodium Q: What e the applications of Cloxacillin sodium Cloxacillin Sodium(Oral) Cloxacillin Sodium Salt Monohydrate (2S,5R,6R)-6-(3-(2-chlorophenyl)-5-Methyl isoxazole-4-formamide)-3,3-twoMethyl-7-oxy-4-sulfur-1-nitrogen bile [3.2.01 Htane-2-sodium cboxylate hydrate CLOXACILLIN SODIUM SALT N-HYDRATE [(2S,5R,6R)-6-({[3-(2-Chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylato-κO]sodium hydrate (1:1) sodium, [(2S,5R,6R)-6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylato-κO]-, hydrate (1:1) Gelstaph orbeninsodiumhydrate sodiumcloxacillinmonohydrate Clozicillin sodium (oral) Cloxacillin sodium RS cloxacillinsodiummonohydrate Cloxacillin s brl-1621sodiumsaltmonohydrate Cloxacillin sodium hydrate in ACN:H2O (9:1) Cloxacillin sodium 7-[[3-(2-chlorophenyl)-5-methyl-oxazol-4-yl]cbonylamino]-3,3-dimethyl-6-oxo-2-thia-5-azabicyclo[3.2.0]htane-4-cboxylic acid sodium salt Staphybiotic C11692100 Cloxacillin sodium monohydrate Ankerbin bactopen (2S,5R,6R)-6-[[[3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Sodium Salt Monohydrate Sodium 6-[3-(2-chlorophenyl)-5-methyl-oxazol-4-yl]cbonylamino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylate hydrate Cloxacillin sodium monohydrate, 10 mM in DMSO Cloxacillin Sodium Monohydrate (CSX) CLOXACILLIN SODIUM SALT MONOHYDRATE Cloxacillin sodium hydrate Oxacillin Impurity E (2S,5R,6R)-6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylic acid, sodium salt, hydrate (1:1:1) (2S,5R,6R)-6-(-chlorobenzeneBase)-5-Methylisoxazole-4-formamideBase)-3.3-Dimethyl-7-oxygenation-4-Sulfur-1-nitrogen bicyclic[3.2.0]Seventh of the ten Heavenly StemsAlkanes-2-sodium cboxylate hydrate α-Amino-p-toluic acid Claxacillin Sodium(Compacted) Orbenin 4-Thia-1-azabicyclo3.2.0htane-2-cboxylic acid, -(2-chlorophenyl)-5-methyl-4-isoxazolylcbonylamino-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, (2S,5R,6R) Sodium (2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate (1:1:1) MFCD00150735 Prostaphilin A Sodium cloxacillin monohydrate //BP Ekvacillin 3-(2-Chlorophenyl)-5-methyl-4-isoxazolylpenicillin Sodium CLOXACILLIN SODIUM WHO(CRM STANDD) Cloxacillin sodium CRS staphobristol-250 EINECS 211-390-9 Cloxacillin Sodium Salt Monohydrate Standd Monosodium (2S,5R,6R)-6-(3-(o-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Monohydrate Cloxacilline sodium 1-hydrate CLOXACILLIN SODIUM SALT HYDRATE VETRANAL sodium (2S,5R,6R)-6-(3-(2-chlorophenyl)-5-methylisoxazole-4-cboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylate hydrate |
| Description | Cloxacillin sodium monohydrate is a semi-synthetic antibiotic that is a chlorinated derivative of oxacillin.Target: AntibacterialCloxacillin sodium (Cloxacap) is a sodium salt of cloxacillin that is a penicillinase-resistant, acid resistant, semi-synthetic penicillin. Cloxacillin sodium exerts a bactericidal action against susceptible microorganisms during the stage of active multiplication. Cloxacillin sodium acts through the inhibition of biosynthesis of cell wall mucopeptides. Cloxacillin sodium is readily absorbed following i.m. administration and rapidly reaches therapeutically effective blood levels. Serum levels are approximately proportional to dosage. Peak plasma concentrations of 15 ug/ml have been observed 30 minutes after an i.m. injection of cloxacillin (Cloxapen, Cloxacap and Orbenin) 500 mg; plasma concentrations may be doubled by administration of a doubled dose. At the end of a 3-hour i.v. infusion of cloxacillin (Cloxapen, Cloxacap and Orbenin) 250 mg given to normal subjects, its plasma concentrations were 15 ug/ml. After 2 hours, plasma concentrations were 0.6 ug/ml [1]. |
|---|---|
| Related Catalog | |
| References |
| Boiling Point | 689.7ºC at 760 mmHg |
|---|---|
| Molecular Formula | C19H19ClN3NaO6S |
| Molecular Weight | 475.88 |
| Flash Point | 370.9ºC |
| PSA | 136.54000 |
| LogP | 0.99210 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H315-H317-H319-H334-H335 |
| Precautionary Statements | P261-P280-P284-P304 + P340-P305 + P351 + P338-P342 + P311 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | XH8920000 |
| HS Code | 2941109900 |
| HS Code | 2941109900 |
|---|