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42540-40-9

42540-40-9 structure
42540-40-9 structure
  • Name: Cefamandole nafate
  • Chemical Name: cefamandole nafate
  • CAS Number: 42540-40-9
  • Molecular Formula: C19H17N6NaO6S2
  • Molecular Weight: 512.495
  • Catalog: API Antibiotics Cephalosporin
  • Create Date: 2018-08-25 19:20:23
  • Modify Date: 2025-08-20 17:05:33
  • Cefamandole nafate is a second-generation broad-spectrum cephalosporin antibiotic.
Name cefamandole nafate
Synonyms 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-(formyloxy)-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, (6R,7R)-
Mandokef
Cefam
cephamandole nafate
EINECS 255-877-4
Cefamandole nafate
O-Formylcefamandole sodium
Bergacef
Cedol
Cemandil
(6R-(6a,7b(R*)))-7-(((Formyloxy)phenylacetyl)amino)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Monosodium Sal
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-(formyloxy)-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, sodium salt, (6R,7R)- (1:1)
CefamandoleNafate
Cefamandole formate sodium
Mandol
Cemandil sodium salt
Cefaseptolo
Sodium O-formylcefamandole
Mandolsan
UNII-8HDO7941DO
Cefamandole formate sodium salt
Sodium (6R,7R)-7-{[(2R)-2-(formyloxy)-2-phenylacetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
sodium (6R,7R)-7-{[(2R)-2-(formyloxy)-2-phenylacetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Kefadol
MFCD00864877
Cefamandole (nafate)
Description Cefamandole nafate is a second-generation broad-spectrum cephalosporin antibiotic.
Related Catalog
Melting Point 190-193ºC
Molecular Formula C19H17N6NaO6S2
Molecular Weight 512.495
Exact Mass 512.054871
PSA 210.04000
Storage condition -20?C Freezer, Under Inert Atmosphere

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XI0380000
CHEMICAL NAME :
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((formyloxy)phenylacetyl)amino)-3- (((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, monosodium salt, (6R-(6-alpha,7-beta(R)))-
CAS REGISTRY NUMBER :
42540-40-9
LAST UPDATED :
199609
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C19-H18-N6-O6-S2.Na
MOLECULAR WEIGHT :
513.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
240 mg/kg/2D-I
TOXIC EFFECTS :
Musculoskeletal - joints
REFERENCE :
SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 78,1268,1985
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
400 ug/kg/1W-I
TOXIC EFFECTS :
Liver - jaundice, other or unclassified
REFERENCE :
DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 19,553,1985
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
408 mg/kg/4D-I
TOXIC EFFECTS :
Blood - change in clotting factors
REFERENCE :
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 146,1125,1986
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
771 mg/kg/9D-I
TOXIC EFFECTS :
Blood - change in clotting factors
REFERENCE :
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 146,1125,1986
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2562 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3915 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
91 gm/kg/13W-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Blood - other changes Blood - changes in erythrocyte (RBC) count
REFERENCE :
JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
23 gm/kg/31D-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Blood - other changes Blood - changes in erythrocyte (RBC) count
REFERENCE :
JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
7 gm/kg/14D-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3878 No. of Facilities: 599 (estimated) No. of Industries: 1 No. of Occupations: 7 No. of Employees: 29927 (estimated) No. of Female Employees: 24672 (estimated)
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger
Hazard Statements H315-H317-H319-H334-H335
Precautionary Statements P261-P280-P284-P304 + P340-P305 + P351 + P338-P342 + P311
Hazard Codes Xn
Risk Phrases 36/37/38-42/43
Safety Phrases 26-36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS XI0380000
HS Code 3003201900
57268-80-1 structure

57268-80-1

~%

42540-40-9 structure

42540-40-9

Literature: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.; MOODY, Harold, Monro; MAAS, Peter, Johannes, Dominicus; SCHMITGES, Thomas Patent: WO2013/57197 A1, 2013 ; Location in patent: Page/Page column 11 ;
24209-38-9 structure

24209-38-9

~%

42540-40-9 structure

42540-40-9

Literature: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.; MOODY, Harold, Monro; MAAS, Peter, Johannes, Dominicus; SCHMITGES, Thomas Patent: WO2013/57197 A1, 2013 ;
20698-91-3 structure

20698-91-3

~%

42540-40-9 structure

42540-40-9

Literature: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.; MOODY, Harold, Monro; MAAS, Peter, Johannes, Dominicus; SCHMITGES, Thomas Patent: WO2013/57197 A1, 2013 ;
65338-32-1 structure

65338-32-1

~%

42540-40-9 structure

42540-40-9

Literature: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.; MOODY, Harold, Monro; MAAS, Peter, Johannes, Dominicus; SCHMITGES, Thomas Patent: WO2013/57197 A1, 2013 ;
HS Code 3003201900
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