Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-Cyclohexyl-6-Methyl-2-[4-(4-Morpholinyl]-imidazo[1,2-a]pyridin-3-amine
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Purity: 98.0%
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Contact: Ms Wang

1353567-32-4

1353567-32-4 structure

Name: N-Cyclohexyl-6-Methyl-2-[4-(4-Morpholinyl]-imidazo[1,2-a]pyridin-3-amine
Chemical Name: cyclohexyl-[6-methyl-2-(4-morpholin-4-yl-phenyl)-imidazo[1,2-a]pyridin-3-yl]-amine
CAS Number: 1353567-32-4
Molecular Formula: C₂₄H₃₀N₄O
Molecular Weight: 390.52
Create Date: 2018-01-28 21:48:46
Modify Date: 2024-03-08 11:12:54
EP6 is a potent 5-Lipoxygenase (5-LO) inhibitor. EP6 inhibits the cell viability of tumor cells without mutagenic activity. EP6 can be used in research of cancer[1].

Name	cyclohexyl-[6-methyl-2-(4-morpholin-4-yl-phenyl)-imidazo[1,2-a]pyridin-3-yl]-amine
Synonyms	N-cyclohexyl-6-methyl-2-(4-morpholinophenyl)imidazo[1,2-a]pyridin-3-amine

Description	EP6 is a potent 5-Lipoxygenase (5-LO) inhibitor. EP6 inhibits the cell viability of tumor cells without mutagenic activity. EP6 can be used in research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
Target	5-Lipoxygenase:0.05 μM (IC50)
In Vitro	EP6 抑制完整多形核白细胞中的 5-LO 活性，IC50 值为 0.16 μM，在无细胞试验中表现出完全抑制效力（纯化的 5-LO 的 IC50 值为 0.05 μM）[1]。
References	[1]. Wisniewska JM, et, al. Molecular characterization of EP6--a novel imidazo[1,2-a]pyridine based direct 5-lipoxygenase inhibitor. Biochem Pharmacol. 2012 Jan 15;83(2):228-40.