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35467-43-7

35467-43-7 structure
35467-43-7 structure
  • Name: Hirsuteine
  • Chemical Name: Hirsuteine
  • CAS Number: 35467-43-7
  • Molecular Formula: C22H26N2O3
  • Molecular Weight: 366.453
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2018-02-17 08:00:00
  • Modify Date: 2024-01-07 20:16:13
  • Hirsuteine is an indole alkaloid extracted from Uncaria genus. Hirsuteine non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes[1].

Name Hirsuteine
Synonyms Indolo[2,3-a]quinolizine-2-acetic acid, 3-ethenyl-1,2,3,4,6,7,12,12b-octahydro-α-(methoxymethylene)-, methyl ester, (αZ,2S,3R,12bS)-
delta18-Hirsutine
(E)-16,17,18,19-Tetradehydro-17-methoxy-17,18-secoyohimban-16-carboxylic AcidMethyl Ester
methyl (3beta,16E)-16-(methoxymethylidene)coryn-18-en-17-oate
Methyl (16Z)-16-(methoxymethylene)coryn-18-en-17-oate
methyl (E)-2-[(2S,3R,12bR)-3-ethenyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate
Description Hirsuteine is an indole alkaloid extracted from Uncaria genus. Hirsuteine non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes[1].
Related Catalog
References

[1]. Watano T, et al. Non-competitive antagonism by hirsuteine of nicotinic receptor-mediated dopamine release from rat pheochromocytoma cells. Jpn J Pharmacol. 1993 Apr;61(4):351-6.

Density 1.2±0.1 g/cm3
Boiling Point 533.2±50.0 °C at 760 mmHg
Molecular Formula C22H26N2O3
Molecular Weight 366.453
Flash Point 276.3±30.1 °C
Exact Mass 366.194336
PSA 54.56000
LogP 3.75
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.623
Hazard Codes Xi
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