1433200-49-7

1433200-49-7 structure

Name: UNC 2400
Chemical Name: unc2400
CAS Number: 1433200-49-7
Molecular Formula: C₃₅H₄₇N₇O₂
Molecular Weight: 597.793
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2018-03-10 10:35:55
Modify Date: 2024-01-14 11:52:51
UNC2400 is a close analog of UNC1999 with >1,000-fold lower potency than UNC1999 as a negative control for cell-based studies[1][2].

Name	unc2400
Synonyms	N-[(1,6-Dimethyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]-1-isopropyl-6-[6-(4-isopropyl-1-piperazinyl)-3-pyridinyl]-N-methyl-1H-indazole-4-carboxamide 1H-Indazole-4-carboxamide, N-[(1,2-dihydro-1,6-dimethyl-2-oxo-4-propyl-3-pyridinyl)methyl]-N-methyl-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-

Description	UNC2400 is a close analog of UNC1999 with >1,000-fold lower potency than UNC1999 as a negative control for cell-based studies[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase Signaling Pathways >> Autophagy >> Autophagy
References	[1]. Kyle D Konze, et al. An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol. 2013;8(6):1324-34. [2]. Bowen Xu, et al. Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Blood. 2015 Jan 8;125(2):346-57.