Name | O-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)hydroxylamine |
---|---|
Synonyms | O-(11-azido-3,6,9-trioxa-undecyl)hydroxylamine |
Description | Aminooxy-PEG3-azide is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-C2-PEG3-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. |
---|---|
Related Catalog | |
Target |
PEGs Non-cleavable |
In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
References |
[1]. Chanhyuk KIM, et al. Optimized chimeric receptor t cell switches and uses thereof. WO2016168766A1. |
Molecular Formula | C8H18N4O4 |
---|---|
Molecular Weight | 234.25300 |
Exact Mass | 234.13300 |
PSA | 112.69000 |
LogP | 0.38986 |
Storage condition | 2-8°C |