Aminooxy-PEG3-azide
Modify Date: 2024-01-09 00:01:09
Aminooxy-PEG3-azide structure
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Common Name | Aminooxy-PEG3-azide | ||
|---|---|---|---|---|
| CAS Number | 1306615-51-9 | Molecular Weight | 234.25300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C8H18N4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Aminooxy-PEG3-azideAminooxy-PEG3-azide is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-C2-PEG3-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. |
| Name | O-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)hydroxylamine |
|---|---|
| Synonym | More Synonyms |
| Description | Aminooxy-PEG3-azide is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-C2-PEG3-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. |
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| Related Catalog | |
| Target |
PEGs Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
[1]. Chanhyuk KIM, et al. Optimized chimeric receptor t cell switches and uses thereof. WO2016168766A1. |
| Molecular Formula | C8H18N4O4 |
|---|---|
| Molecular Weight | 234.25300 |
| Exact Mass | 234.13300 |
| PSA | 112.69000 |
| LogP | 0.38986 |
| Storage condition | 2-8°C |
| O-(11-azido-3,6,9-trioxa-undecyl)hydroxylamine |