139115-89-2

139115-89-2 structure

Name: Hydroxy-PEG3-MS
Chemical Name: 2-(2-(2-((Methanesulfonyl)oxy)ethoxy)ethoxy)ethanol
CAS Number: 139115-89-2
Molecular Formula: C₇H₁₆O₆S
Molecular Weight: 228.26300
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-26 16:34:56
Modify Date: 2024-01-02 10:31:23
Hydroxy-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-(2-(2-((Methanesulfonyl)oxy)ethoxy)ethoxy)ethanol
Synonyms	2-(2-(2-hydroxyethoxy)ethoxy)ethyl methanesulfonate 8-hydroxy-3,6-dioxaoctyl methanesulphonate triethylene glycol Hydroxy-PEG3-MS

Description	Hydroxy-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562