327062-46-4

327062-46-4 structure

Name: NS 19504
Chemical Name: ns19504
CAS Number: 327062-46-4
Molecular Formula: C₁₀H₉BrN₂S
Molecular Weight: 269.16100
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2018-02-04 22:19:36
Modify Date: 2025-08-27 02:30:32
NS19504 is a Ca2+-activated K+ channel (BK channel, KCa1.1 channel) activator (EC50=11.0 µM) with relaxing effect on bladder smooth muscle spontaneous phasic contractions[1].

Name	ns19504
Synonyms	5-[(4-bromophenyl)methyl]-1,3-thiazol-2-amine 2-amino-5-(4-bromobenzyl)-1,3-thiazole

Description	NS19504 is a Ca2+-activated K+ channel (BK channel, KCa1.1 channel) activator (EC50=11.0 µM) with relaxing effect on bladder smooth muscle spontaneous phasic contractions[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	EC50: 11.0 µM (BK channel)[1]
In Vitro	NS19504 increases BK currents in freshly isolated guinea pig bladder smooth muscle cells and whole-cell. NS19504 increases the whole-cell currents response to 127 %, 194 %, 258 %, 561 % of control at a concentration of 0.32 µM, 1.0 µM, 3.2 µM and 10 µM, respectively[1].
References	[1]. Nausch B, et al. NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions. J Pharmacol Exp Ther. 2014 Sep;350(3):520-30.