150399-21-6
150399-21-6 structure
- Name: Balsalazide disodium
- Chemical Name: Balsalazide disodium
- CAS Number: 150399-21-6
- Molecular Formula: C17H17N3Na2O8
- Molecular Weight: 437.312
- Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
- Create Date: 2018-07-19 12:30:46
- Modify Date: 2024-01-03 09:32:28
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Balsalazide sodium hydrate could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
| Name | Balsalazide disodium |
|---|---|
| Synonyms |
Balsalazide Disodium Salt Dihydrate
Balsalzide Disodium Hydrate 5-[4-(2-Carboxyethylcarbamoyl)phenylazo]salicylic Acid Disodium Salt Dihydrate sodium, μ-[5-[(E)-2-[4-[[[2-(carboxy-κO)ethyl]amino]carbonyl]phenyl]diazenyl]-2-hydroxybenzoato(2-)-κO]-, hydrate (1:2) Balsalazide disodium Sodium 5-[(E)-{4-[(2-carboxylatoethyl)carbamoyl]phenyl}diazenyl]-2-hydroxybenzoate hydrate (2:1:2) Benzoic acid, 5-[(E)-2-[4-[[(2-carboxyethyl)amino]carbonyl]phenyl]diazenyl]-2-hydroxy-, sodium salt, hydrate (1:2:2) Balsalazide (sodium hydrate) |
| Description | Balsalazide sodium hydrate could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway. |
|---|---|
| Related Catalog | |
| Target |
STAT3 IL-6 |
| In Vivo | At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group[1]. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug[2]. |
| References |
| Molecular Formula | C17H17N3Na2O8 |
|---|---|
| Molecular Weight | 437.312 |
| Exact Mass | 437.081116 |
| PSA | 172.77000 |
| LogP | 0.30320 |
| RIDADR | UN 2222 3 / PGIII |
|---|---|
| HS Code | 2853009090 |
| HS Code | 2853009090 |
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