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144-83-2

144-83-2 structure
144-83-2 structure
  • Name: Sulfapyridine
  • Chemical Name: sulfapyridine
  • CAS Number: 144-83-2
  • Molecular Formula: C11H11N3O2S
  • Molecular Weight: 249.289
  • Catalog: API Antibiotics Other antibiotics
  • Create Date: 2018-02-09 08:00:00
  • Modify Date: 2026-07-01 16:12:55
  • Sulfapyridine(Dagenan) is a sulfonamide antibacterial.Target: AntibacterialSulfapyridine(Dagenan) is a sulfonamide antibacterial. Sulfapyridine is not prescribed for the treatment in humans any more. However, it may be used to treat Linear IgA Disease. It is a good antibacterial drug, but its water solubility is very dependent on PH. Thus, there is a risk of crystallization within the bladder or urethra, which could lead to pain or blockage. The drug sulfasalazine is structurally one molecule of mesalamine linked to one molecule of Sulfapyridine with an azo bond [1].
Name sulfapyridine
Synonyms 2-(4-Aminobenzenesulfonamido)pyridine
WLN: T6NJ BMSWR DZ
N-2-pyridinylsulfanilamide
4-Amino-N-(2-pyridinyl)benzenesulfonamide
n(sup1)-2-pyridyl-sulfanilamid
Piridazol
MFCD00038036
CTG-B43a
M & B 693
SULFAPYRIDINE,POWDER
n(sup1)-2-pyridylsulfanilamide
Plurazol
Sulphapyridine
T6NJ BMSWR DZ
4-amino-N-pyridin-2-ylbenzenesulfonamide
2-(4-AMINOBENZENESULFONAMIDO)PYRIDINE
N1-(PYRIDIN-2-YL)SULFANILAMIDE
Sulfanilamide, N(sup 1)-2-pyridyl
4-Amino-N-[2-pyridyl]benzene sulfonamide (N1-(Pyridin-2-yl)sulfanilamide
Ronin
N'-2-PYRIDYLSULFANILIDE
N'-2-Pyridylsulfanilide
Sulfapyridine (USP)
Sulfapyridine,SodiumSalt
LABOTEST-BB LT00772295
2-(4-Aminobenzenesulfonamido)pyridine N'-2-Pyridylsulfanilide 2-Sulfanilamidopyridine
Sulfidin
Sulfanilamide, N1-2-pyridyl
Pyridazol
SULFAPYRIDINE
4-AMINO-N-2-PYRIDINYL-BENZENESULFONAMIDE
Monoclonal Anti-THAP11 antibody produced in mouse
Sulfasalazine Impurity J
Sulphapyridin
4-((2-pyridylamino)sulfonyl)aniline
N1-2-Pyridylsulfanilamide
BENZENESULPHANAMIDE,4-AMINO-N-(2-PYRIDINYL)
2-Sulfanilamidopyridine
CTG-B45d
2-sulfapyridine
N-2-Pyridylsulfanilamide
Stipulmon
4-Amino-N-[2-pyridyl]benzene sulfonamide N1-(Pyridin-2-yl)sulfanilamide 2-(4-Aminobenzenesulfonamido)pyridine 2-Sulfanilamidopyridine N'-2-Pyridylsulfanilide
N(Sup1)-Pyridylsulfanilamide
EINECS 205-642-7
2-Sulfanilamidopyr
4-AMINO-N-[2-PYRIDYL]BENZENE SULFONAMIDE
Pyriamid
Sulfapyridine Solution, 100ppm
2-(P-AMINOBENZENESULFONAMIDO)PYRIDINE (SULFAPYRIDINE)
4-Amino-N-(pyridin-2-yl)benzenesulfonamide
4-AMINO-N-PYRIDIN-2-YL-BENZENESULFONAMIDE
Sulfidine
Sulfapyridine melting point standd
HRIHFB2206
Trianon
2-SULFANILAMIDOPYRIDINE
Sulfapyridine (Dagenan)
Relbapiridina
N’-2-Pyridylsulfanilamide
Strtosilpyridine
p-amino-N-2-pyridyl-benzenesulfonamide
Sulfadipyridine
Sulfanilamide, N1-2(1H)-pyridylidene
Thiostal
THAP11
SULFAPYRIDINE VETRANAL (4-AMINO-N-(2-PYR IDINYL)BENZENESULFONAMIDE)
Sulfapyridine(from Bovine Brain)nzopyrylospiran [Photochromic Compound]a dry weight basis)l as Aldehyde in Ethyl Acetate) [for Offensive Odors Analysis] (1mlX5)
TIMTEC-BB SBB003154
Description Sulfapyridine(Dagenan) is a sulfonamide antibacterial.Target: AntibacterialSulfapyridine(Dagenan) is a sulfonamide antibacterial. Sulfapyridine is not prescribed for the treatment in humans any more. However, it may be used to treat Linear IgA Disease. It is a good antibacterial drug, but its water solubility is very dependent on PH. Thus, there is a risk of crystallization within the bladder or urethra, which could lead to pain or blockage. The drug sulfasalazine is structurally one molecule of mesalamine linked to one molecule of Sulfapyridine with an azo bond [1].
Related Catalog
References

[1]. Hanauer, S.B., Review article: high-dose aminosalicylates to induce and maintain remissions in ulcerative colitis. Aliment Pharmacol Ther, 2006. 24 Suppl 3: p. 37-40.
Density 1.4±0.1 g/cm3
Boiling Point 473.5±51.0 °C at 760 mmHg
Melting Point 191-193°C
Molecular Formula C11H11N3O2S
Molecular Weight 249.289
Flash Point 240.2±30.4 °C
Exact Mass 249.057190
PSA 93.46000
LogP 0.03
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.674
Storage condition 2-8°C
Stability Stable. Combustible. Protect from light. Incompatible with strong oxidizing agents.
Water Solubility <0.1 g/100 mL at 22 ºC

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DA9625000
CHEMICAL NAME :
Benzenesulfonamide, 4-amino-N-(2-pyridinyl)-
CAS REGISTRY NUMBER :
144-83-2
LAST UPDATED :
199701
DATA ITEMS CITED :
19
MOLECULAR FORMULA :
C11-H11-N3-O2-S
MOLECULAR WEIGHT :
249.31
WISWESSER LINE NOTATION :
T6NJ BMSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15800 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16600 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1150 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
20 gm/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
8400 mg/kg/21D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - hematuria Kidney, Ureter, Bladder - structural or functional changes in ureter Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
135 mg/kg/9W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Tumorigenic - tumors at site of application
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
13482 mg/kg
SEX/DURATION :
male 6 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
10080 mg/kg
SEX/DURATION :
male 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
12600 mg/kg
SEX/DURATION :
male 35 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4200 mg/kg
SEX/DURATION :
male 35 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
46200 mg/kg
SEX/DURATION :
male 60 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
Micronucleus test

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
1667 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 283,59,1992 *** REVIEWS *** TOXICOLOGY REVIEW JMSHAO Journal of the Mount Sinai Hospital (New York). (New York, NY) V.1-36, 1934-69. For publisher information, see MSJMAZ. Volume(issue)/page/year: 10,343,1943
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS DA9625000
HS Code 2935009090
HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%
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