477775-77-2

477775-77-2 structure

Name: m-PEG3-succinimidyl carbonate
Chemical Name: 2,5-dioxopyrrolidin-1-yl (2-(2-(2-methoxyethoxy)ethoxy)ethyl)carbonate
CAS Number: 477775-77-2
Molecular Formula: C₁₂H₁₉NO₈
Molecular Weight: 305.28100
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-16 11:51:27
Modify Date: 2024-01-10 17:28:31
m-PEG3-succinimidyl carbonate is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

Name	2,5-dioxopyrrolidin-1-yl (2-(2-(2-methoxyethoxy)ethoxy)ethyl)carbonate
Synonyms	8-methoxy-3,6-dioxaoctyl N-succinimidyl carbonate carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester 2-[2-(2-methoxy-ethoxy)-ethoxy]-ethyl ester activated triethylene glycol monomethyl oligomer

Description	m-PEG3-succinimidyl carbonate is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Miller MA, et al. Amphiphilic conjugates of human brain natriuretic peptide designed for oral delivery: in vitro activity screening. Bioconjug Chem. 2006 Mar-Apr;17(2):267-74.