152946-68-4
152946-68-4 structure
- Name: Nolatrexed dihydrochloride
- Chemical Name: 2-amino-6-methyl-5-pyridin-4-ylsulfanyl-1H-quinazolin-4-one,dihydrochloride
- CAS Number: 152946-68-4
- Molecular Formula: C14H14Cl2N4OS
- Molecular Weight: 357.258
- Catalog: Signaling Pathways Apoptosis Thymidylate Synthase
- Create Date: 2018-03-06 08:00:00
- Modify Date: 2025-08-22 08:53:23
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Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase[1]. Nolatrexed dihydrochloride (AG 337) has anti-cancer activity, induces cell cycle arrest in S phase of cancer cells[2].
| Name | 2-amino-6-methyl-5-pyridin-4-ylsulfanyl-1H-quinazolin-4-one,dihydrochloride |
|---|---|
| Synonyms |
2-Amino-6-methyl-5-(4-pyridinylsulfanyl)-4(1H)-quinazolinone dihydrochloride
Thymitaq 2-Amino-6-methyl-5-(pyridin-4-ylsulfanyl)quinazolin-4(3H)-one dihydrochloride MFCD00917041 4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio)-, hydrochloride (1:2) Nolatrexed dihydrochloride AG 337 |
| Description | Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase[1]. Nolatrexed dihydrochloride (AG 337) has anti-cancer activity, induces cell cycle arrest in S phase of cancer cells[2]. |
|---|---|
| Related Catalog | |
| Target |
Ki: 11 nM (Human Thymidylate Synthase)[1] |
| References |
| Boiling Point | 493.6ºCat 760 mmHg |
|---|---|
| Melting Point | 301-302ºC |
| Molecular Formula | C14H14Cl2N4OS |
| Molecular Weight | 357.258 |
| Flash Point | 252.3ºC |
| Exact Mass | 356.026550 |
| PSA | 109.96000 |
| LogP | 4.54510 |
| Storage condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| Stability | Hygroscopic |