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132834-56-1

132834-56-1 structure
132834-56-1 structure
  • Name: Org 12962
  • Chemical Name: 1-[6-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine
  • CAS Number: 132834-56-1
  • Molecular Formula: C10H11ClF3N3
  • Molecular Weight: 265.66300
  • Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
  • Create Date: 2018-12-01 20:53:48
  • Modify Date: 2025-09-21 12:06:31
  • Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively[1][3].Org-12962 displays antiaversive effects in a rat model of panic-like anxiety[2].
Name 1-[6-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine
Synonyms MFCD00892750
Description Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively[1][3].Org-12962 displays antiaversive effects in a rat model of panic-like anxiety[2].
Related Catalog
Target

5-HT2C Receptor:7.01 (pEC50)

5-HT2A Receptor:6.38 (pEC50)

5-HT2B Receptor:6.28 (pEC50)

In Vivo Org-12962 (intraperitoneal injection; 0.3-3.2 mg/kg) significantly increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). Org-12962 is dissolved or microsuspended in 0.3% v/v Tween 80 in physiological saline (NaCl 0.9%)[1]. Animal Model: Male Wistar rats[2] Dosage: 0.3 mg/kg, 1 mg/kg, 3.2 mg/kg Administration: Intraperitoneal injection; 0.3-3.2 mg/kg Result: Induced a dose-related antipanic-like effect.
References

[1]. Porter RH,et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.Br J Pharmacol. 1999 Sep;128(1):13-20.

[2]. Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8.

[3]. Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.Int J Pharm. 2003 Sep 16;263(1-2):113-22.
Density 1.454g/cm3
Boiling Point 286.004ºC at 760 mmHg
Molecular Formula C10H11ClF3N3
Molecular Weight 265.66300
Flash Point 126.771ºC
Exact Mass 265.05900
PSA 28.16000
LogP 2.55720
Vapour Pressure 0.001mmHg at 25°C
Index of Refraction 1.541
HS Code 2933990090
Precursor  2

DownStream  0

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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