24967-27-9
24967-27-9 structure
- Name: N-acetyl-2,3-didehydro-2-deoxyneuraminic acid
- Chemical Name: n-acetylneuraminic acid, 2,3-dehydro-2-deoxy-, sodium salt
- CAS Number: 24967-27-9
- Molecular Formula: C11H17NO8
- Molecular Weight: 291.25500
- Catalog: Signaling Pathways Anti-infection Influenza Virus
- Create Date: 2018-12-27 12:28:46
- Modify Date: 2025-08-21 21:17:38
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N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC50s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity[1][2].
| Name | n-acetylneuraminic acid, 2,3-dehydro-2-deoxy-, sodium salt |
|---|---|
| Synonyms |
5-acetamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galactonon-2-enonic acid
2,3,4-TRIMETHYL-3-PENTANOL 5-acetamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enoic acid N-acetyl-2,3-didehydro-2-deoxyneuraminic acid 1,3-DEHYDRO-2-DEOXY-N-ACETYLNEURAMINIC ACID 2,3-DEHYDRO-2-DEOXY-N-ACETYLNEURAMINIC ACID 2,3-Dehydro-2-deoxy-N-acetylneuraminic AcidDANA MFCD00057470 N-Acetyl-2,3-dehydro-2-deoxyneuraminic acid 2,3-didehydro-2-deoxy-N-acetylneuraminic acid 2-deoxy-2,3-dehydro-n-acetylneuraminicacid EINECS 246-550-7 |
| Description | N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC50s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) (10-100 μM) signifcantly inhibits sialidase activity in INS-1D cells[4]. |
| In Vivo | N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) (10 mg/kg; i.p.; daily) attenuates pulmonary fibrosis in a mouse model[3]. Animal Model: Mice (Mouse model of pulmonary fibrosis)[3] Dosage: 10 mg/kg Administration: I.p.; daily (starting at day 10 after Bleomycin, and then euthanized at day 21) Result: Inhibition of sialidases starting at day 10 after bleomycin attenuates fibrosis. |
| References |
| Density | 1.58g/cm3 |
|---|---|
| Boiling Point | 773.4ºC at 760 mmHg |
| Melting Point | 227-228ºC |
| Molecular Formula | C11H17NO8 |
| Molecular Weight | 291.25500 |
| Flash Point | 421.6ºC |
| Exact Mass | 291.09500 |
| PSA | 156.55000 |
| Vapour Pressure | 1.27E-27mmHg at 25°C |
| Index of Refraction | 1.612 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| Precursor 4 | |
|---|---|
| DownStream 0 | |
