Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,3-Benzodioxolane-5-carboxylicacid4'-benzyloxy-3'-methoxybenzylidenehydrazide
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329691-12-5

329691-12-5 structure

Name: FPR A14
Chemical Name: N'-(4-(benzyloxy)-3-methoxybenzylidene)benzo[d][1,3]dioxole-5-carbohydrazide
CAS Number: 329691-12-5
Molecular Formula: C₂₃H₂₀N₂O₅
Molecular Weight: 404.41500
Catalog: Research Areas Neurological Disease
Create Date: 2018-04-20 14:15:43
Modify Date: 2024-01-19 17:32:30
FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca2+ mobilization and chemotaxis with EC50s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation[1][2].

Name	N'-(4-(benzyloxy)-3-methoxybenzylidene)benzo[d][1,3]dioxole-5-carbohydrazide

Description	FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca2+ mobilization and chemotaxis with EC50s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation[1][2].
Related Catalog	Research Areas >> Neurological Disease
In Vitro	FPR-A14 (化合物 14) 激活 Ca2+ 释放，在人中性粒细胞中 EC50 为 630 nM。FPR-A14 是一种中性粒细胞化学引诱剂，剂量依赖性地诱导中性粒细胞迁移，EC50 值为 42 nM[1]。 FPR-A14 (1-10 μM; 48 小时) 在小鼠神经母细胞瘤 N2a 细胞中引起细胞分化百分比显着增加，分别为 4μM (32.0%)、6μM (64.9%)、8μM (89.1%) 和 10μM (93.3%)。FPRa14 (100μM) 在 IMR-32 和 SH-SY5Y 细胞中产生相似的作用[2]。
References	[1]. Igor A Schepetkin, et al. High-throughput screening for small-molecule activators of neutrophils: identification of novel N-formyl peptide receptor agonists. Mol Pharmacol. 2007 Apr;71(4):1061-74. [2]. Peter J G Cussell, et al. The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically. inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One. 2019 Jun 6;14(6):e0217815.