131665-94-6

131665-94-6 structure

Name: Cyclohexane-PEG1-Br
Chemical Name: (2-bromoethoxy)cyclohexane
CAS Number: 131665-94-6
Molecular Formula: C₈H₁₅BrO
Molecular Weight: 207.10800
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-02-21 03:00:37
Modify Date: 2024-01-14 15:49:55
Cyclohexane-PEG1-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	(2-bromoethoxy)cyclohexane
Synonyms	2-bromoethoxy cyclohexane

Description	Cyclohexane-PEG1-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562