Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5,6-bis(4-methoxyphenyl)-3-methyl-1,2,4-triazine
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Purity: 98.0%
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63119-27-7

63119-27-7 structure

63119-27-7 structure

Name: Anitrazafen
Chemical Name: 5,6-bis(4-methoxyphenyl)-3-methyl-1,2,4-triazine
CAS Number: 63119-27-7
Molecular Formula: C₁₈H₁₇N₃O₂
Molecular Weight: 307.34600
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-06-22 12:12:20
Modify Date: 2024-01-10 14:13:45
Anitrazafen is a topically effective antiinflammatory agent.

Name	5,6-bis(4-methoxyphenyl)-3-methyl-1,2,4-triazine
Synonyms	ANITRAZAFEN Anitrazafene Anitrazafenum Anitrazafeno

Description	Anitrazafen is a topically effective antiinflammatory agent.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vivo	Anitrazafen is a topically effective antiinflammatory agent. The disposition of 14C in normal and in bile-duct cannulated rats after oral administration of a single dose of 25 mg/kg of [3-14C]Anitrazafen shows the drug to be well absorbed from the gastro-intestinal tract and biliary excretion to be the major route of elimination of drug and/or metabolites. Plasma concentrations of total 14C after subcutaneous administration of [3-14C]Anitrazafen in corn oil solution are about one half those found after oral administration[1].
Animal Admin	Male albino rats (200 to 250 g) are fasted for 24 h before experiment. [3-14C]Anitrazafen (25 mg/kg) is administered orally to twelve rats. At specific times after dosing, three animals are killed by decapitation and samples of blood and appropriate tissues are removed. Duplicate weighed samples of blood and each tissue are removed for 14C assay[1].
References	[1]. Sullivan HR, et al. Absorption and metabolism of anitrazafen, a topically effective anti-inflammatory agent, in the rat. Xenobiotica. 1981 Jan;11(1):9-22.

Density	1.164g/cm3
Boiling Point	482.8ºC at 760 mmHg
Molecular Formula	C₁₈H₁₇N₃O₂
Molecular Weight	307.34600
Flash Point	172.1ºC
Exact Mass	307.13200
PSA	57.13000
LogP	3.53120
Index of Refraction	1.58
Storage condition	2-8℃

HS Code	2933699090

1779-49-3 structure

1779-49-3

59663-39-7 structure

59663-39-7

~%

63119-27-7 structure

63119-27-7

Literature: Eli Lilly and Company Patent: US4021553 A1, 1977 ;

Precursor 2
1779-49-3 59663-39-7
DownStream 0

HS Code	2933699090
Summary	2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%