1198408-78-4

1198408-78-4 structure

Name: LDN-211904
Chemical Name: ldn-211904
CAS Number: 1198408-78-4
Molecular Formula: C₂₁H₂₁ClN₄O₅
Molecular Weight: 444.86800
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Ephrin Receptor
Create Date: 2018-05-11 22:52:19
Modify Date: 2024-01-10 10:55:52
LDN-211904 oxalate (compound 32) is a potent and selective EphB3 inhibitor with an IC50 of 0.079 µM. LDN-211904 oxalate shows good metabolic stability in mouse liver microsomes. LDN-211904 oxalate with cetuximab could be effective in inhibiting STAT3-activated CSC stemness and cetuximab resistance in CRC[1][2].

Name	ldn-211904
Synonyms	LDN211904 N-(2-chlorophenyl)-6-(piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide oxalate

Description	LDN-211904 oxalate (compound 32) is a potent and selective EphB3 inhibitor with an IC50 of 0.079 µM. LDN-211904 oxalate shows good metabolic stability in mouse liver microsomes. LDN-211904 oxalate with cetuximab could be effective in inhibiting STAT3-activated CSC stemness and cetuximab resistance in CRC[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Ephrin Receptor
Target	IC50: 0.079 µM (EphB3)[1]
References	[1]. Qiao L, et al. Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6122-6. [2]. Park SH, et al. Sonic hedgehog pathway activation is associated with cetuximab resistance and EPHB3 receptor induction in colorectal cancer. Theranostics. 2019 Apr 12;9(8):2235-2251.