LDN-211904
Modify Date: 2024-01-10 10:55:52
LDN-211904 structure
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Common Name | LDN-211904 | ||
|---|---|---|---|---|
| CAS Number | 1198408-78-4 | Molecular Weight | 444.86800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H21ClN4O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LDN-211904LDN-211904 oxalate (compound 32) is a potent and selective EphB3 inhibitor with an IC50 of 0.079 µM. LDN-211904 oxalate shows good metabolic stability in mouse liver microsomes. LDN-211904 oxalate with cetuximab could be effective in inhibiting STAT3-activated CSC stemness and cetuximab resistance in CRC[1][2]. |
| Name | ldn-211904 |
|---|---|
| Synonym | More Synonyms |
| Description | LDN-211904 oxalate (compound 32) is a potent and selective EphB3 inhibitor with an IC50 of 0.079 µM. LDN-211904 oxalate shows good metabolic stability in mouse liver microsomes. LDN-211904 oxalate with cetuximab could be effective in inhibiting STAT3-activated CSC stemness and cetuximab resistance in CRC[1][2]. |
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| Related Catalog | |
| Target |
IC50: 0.079 µM (EphB3)[1] |
| References |
| Molecular Formula | C21H21ClN4O5 |
|---|---|
| Molecular Weight | 444.86800 |
| Exact Mass | 444.12000 |
| PSA | 133.03000 |
| LogP | 3.26440 |
| LDN211904 |
| N-(2-chlorophenyl)-6-(piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide oxalate |