1453071-47-0

1453071-47-0 structure

Name: KDM2/7-IN-1
Chemical Name: ncdm-64
CAS Number: 1453071-47-0
Molecular Formula: C₁₅H₂₇NO₄
Molecular Weight: 285.37900
Catalog: Signaling Pathways Epigenetics Histone Demethylase
Create Date: 2018-11-25 17:42:37
Modify Date: 2024-01-09 08:47:44
KDM2/7-IN-1 (TC-E 5002) is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). KDM2/7-IN-1 inhibits growth of HeLa and KYSE-150 cancer cells in vitro[1].

Name	ncdm-64
Synonyms	3-(9-cyclopropyl-N-hydroxynonanamido)propanoic acid 3-(N-hydroxy-9-cyclopropylnonanamido)propanoic acid

Description	KDM2/7-IN-1 (TC-E 5002) is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). KDM2/7-IN-1 inhibits growth of HeLa and KYSE-150 cancer cells in vitro[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Demethylase
References	[1]. Suzuki T, et al. Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J Med Chem. 2013 Sep 26;56(18):7222-31.