552830-51-0

552830-51-0 structure

Name: Resolvin E1
Chemical Name: Resolvin E1
CAS Number: 552830-51-0
Molecular Formula: C₂₀H₃₀O₅
Molecular Weight: 350.44900
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-05-20 03:16:02
Modify Date: 2024-01-01 19:25:23
Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production[1][2].

Name	Resolvin E1
Synonyms	(5S,12R,18R)-(6Z,8E,10E,14Z,16E)-5,12,18-trihydroxy-eicosa-6,8,10,14,16-pentaenoic acid (5S,6Z,8E,10E,12R,14Z,16E,18R)-5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid 5S,12R,18R-triHEPE resolvin E1 RvE1 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid

Description	Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	Human Endogenous Metabolite
In Vitro	Resolvin E1 (0.1-100 nM) gives concentration-dependent inhibition of TNF-α–induced NF-κB activation with an EC50 of ∼1.0 nM in ChemR23-transfected cells. Resolvin E1 (100 nM) increases phosphorylation of extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase both in peripheral blood monocytes and HEK-ChemR23 cells[2].Resolvin E1 specifically interacts with the LTB4 receptor BLT1 on neutrophils and ChemR23 on monocytes to regulate leukocytes during inflammation. Resolvin E1 also stimulates the uptake and clearance of local cytokine[3].
In Vivo	Resolvin E1 (1.0 μg per mouse; 50 μg/kg; i.p.; on days -8, -1, and 0) protects mice from TNBS (2,4,6-trinitrobenzene sulfonic acid) colitis[1]. Animal Model: 6- to 8-week-old female BALB/c mice (TNBS colitis model)[1] Dosage: 1.0 μg per mouse; 50 μg/kg Administration: i.p.; on days -8, -1, and 0 before the induction of colitis Result: Reduced overall mortality, which was 25% and 62.5% at 1.0 μg per mouse and 50 μg/kg, respectively.
References	[1]. Arita M, et al. Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7671-6. [2]. Schwab JM, et al. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature. 2007 Jun 14;447(7146):869-74. [3]. Hasturk H, et al. Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissuehomeostasis in vivo. J Immunol. 2007 Nov 15;179(10):7021-9.

Molecular Formula	C₂₀H₃₀O₅
Molecular Weight	350.44900
Exact Mass	350.20900
PSA	97.99000
LogP	2.90510

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