152755-31-2

152755-31-2 structure

Name: LY 295427
Chemical Name: ly295427
CAS Number: 152755-31-2
Molecular Formula: C₃₀H₅₂O
Molecular Weight: 428.73300
Catalog: Research Areas Metabolic Disease
Create Date: 2018-01-22 12:56:23
Modify Date: 2024-01-11 11:46:46
LY 295427 is a LDL receptor modulator and a hypocholesterolemic agent. LY 295427 derepresses the transcription of the LDLR (LDL Receptor). LY 295427 can be used for hypercholesterolemia research[1][2][3].

Name	ly295427
Synonyms	[4α,5α]-4-(2-propenyl)cholestan-3α-ol (3α,4α,5α)-4-(2-propenyl)cholestan-3-ol (3R,4S,5S,8S,9S,10R,13R,14S,17R)-4-Allyl-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-ol

Description	LY 295427 is a LDL receptor modulator and a hypocholesterolemic agent. LY 295427 derepresses the transcription of the LDLR (LDL Receptor). LY 295427 can be used for hypercholesterolemia research[1][2][3].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	LY 295427 时间依赖性地增加中国仓鼠卵巢 (CHO) 细胞对 25-OH chol 的摄取[1]。 LY 295427 (2.9 μM) 提高 30% LDL 受体启动子的活性[2]。
In Vivo	LY 295427 剂量依赖性地降低胆固醇-椰子油喂养的仓鼠 LDL-R 转录水平，ED50 值为 40 mg/kg/day[3]。
References	[1]. Bowling N, et al. LY295427, a novel hypocholesterolemic agent, enhances [3H]25-hydroxycholesterol binding to liver cytosolic proteins. J Lipid Res. 1996 Dec;37(12):2586-98. [2]. George Chang, et al. Low density lipoprotein receptor up-regulation. Expert Opinion on Therapeutic Patents. Volume 9, 1999-Issue 5. [3]. Bensch WR, et al. Effects of LY295427, a low-density lipoprotein (LDL) receptor up-regulator, on LDL receptor gene transcription and cholesterol metabolism in normal and hypercholesterolemic hamsters. J Pharmacol Exp Ther. 1999 Apr;289(1):85-92.