Shanghai Nianxing Industrial Co., Ltd
China
Product Name: NS3694
Price: Check
Purity: 99.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: NS3694
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

426834-38-0

426834-38-0 structure

426834-38-0 structure

Name: NS3694
Chemical Name: 4-chloro-2-[[3-(trifluoromethyl)phenyl]carbamoylamino]benzoic acid
CAS Number: 426834-38-0
Molecular Formula: C₁₅H₁₀ClF₃N₂O₃
Molecular Weight: 358.70000
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2016-10-18 03:35:12
Modify Date: 2024-01-08 11:24:27
NS3694, a diarylurea compound, is an apoptosome inhibitor. NS3694 inhibits apoptosome formation and caspase activation[1].

Name	4-chloro-2-[[3-(trifluoromethyl)phenyl]carbamoylamino]benzoic acid
Synonyms	Apoptosis Inhibitor II,NS3694 NS3694

Description	NS3694, a diarylurea compound, is an apoptosome inhibitor. NS3694 inhibits apoptosome formation and caspase activation[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	When cell extracts are stimulated with cytochrome c and dATP in the presence of NS3694 (10-100 μM; 120 min), a dose-dependent inhibition of caspase 9, 3, and 7 processing, DFF45/ICAD and PARP cleavage, and DEVDase activity is observed[1]. NS3694 (10-100 μM) inhibits TNF-induced effector caspase activation and apoptosis in MCF-casp3 cells[1]. NS3694 specifically suppresses the cytochrome C-induced formation of apoptosome complex and caspase-9 activation, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9[1]. Western Blot Analysis[1] Cell Line: HeLa cells Concentration: 10 μM, 50 μM, 100 μM Incubation Time: 120 min Result: Inhibited cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates.
References	[1]. Ulrik Lademann, et al. Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex. Mol Cell Biol. 2003 Nov;23(21):7829-37.

Density	1.574g/cm3
Boiling Point	378.448ºC at 760 mmHg
Molecular Formula	C₁₅H₁₀ClF₃N₂O₃
Molecular Weight	358.70000
Flash Point	182.679ºC
Exact Mass	358.03300
PSA	78.43000
LogP	4.84700
Index of Refraction	1.638
Storage condition	-20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

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