426834-38-0
426834-38-0 structure
- Name: NS3694
- Chemical Name: 4-chloro-2-[[3-(trifluoromethyl)phenyl]carbamoylamino]benzoic acid
- CAS Number: 426834-38-0
- Molecular Formula: C15H10ClF3N2O3
- Molecular Weight: 358.70000
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2016-10-18 03:35:12
- Modify Date: 2024-01-08 11:24:27
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NS3694, a diarylurea compound, is an apoptosome inhibitor. NS3694 inhibits apoptosome formation and caspase activation[1].
| Name | 4-chloro-2-[[3-(trifluoromethyl)phenyl]carbamoylamino]benzoic acid |
|---|---|
| Synonyms |
Apoptosis Inhibitor II,NS3694
NS3694 |
| Description | NS3694, a diarylurea compound, is an apoptosome inhibitor. NS3694 inhibits apoptosome formation and caspase activation[1]. |
|---|---|
| Related Catalog | |
| In Vitro | When cell extracts are stimulated with cytochrome c and dATP in the presence of NS3694 (10-100 μM; 120 min), a dose-dependent inhibition of caspase 9, 3, and 7 processing, DFF45/ICAD and PARP cleavage, and DEVDase activity is observed[1]. NS3694 (10-100 μM) inhibits TNF-induced effector caspase activation and apoptosis in MCF-casp3 cells[1]. NS3694 specifically suppresses the cytochrome C-induced formation of apoptosome complex and caspase-9 activation, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9[1]. Western Blot Analysis[1] Cell Line: HeLa cells Concentration: 10 μM, 50 μM, 100 μM Incubation Time: 120 min Result: Inhibited cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates. |
| References |
| Density | 1.574g/cm3 |
|---|---|
| Boiling Point | 378.448ºC at 760 mmHg |
| Molecular Formula | C15H10ClF3N2O3 |
| Molecular Weight | 358.70000 |
| Flash Point | 182.679ºC |
| Exact Mass | 358.03300 |
| PSA | 78.43000 |
| LogP | 4.84700 |
| Index of Refraction | 1.638 |
| Storage condition | -20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |