57651-82-8

57651-82-8 structure

Name: vitamin D3
Chemical Name: vitamin D3
CAS Number: 57651-82-8
Molecular Formula: C₂₇H₄₄O
Molecular Weight: 384.63800
Catalog: Signaling Pathways Stem Cell/Wnt Hedgehog
Create Date: 2018-06-18 07:21:43
Modify Date: 2024-01-08 08:28:41
3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4), a Vitamin D3 analogue, is a Hedgehog pathway inhibitor with an IC50 of 39.2 μM measured in U87MG cells[1].

Name	vitamin D3
Synonyms	(3R,5Z,7E)-9,10-seco-cholesta-5,7,10(19)-trien-3-ol (R)-3-[2-[(1R,3aS,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexanol 3-epi-vitamin D

Description	3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4), a Vitamin D3 analogue, is a Hedgehog pathway inhibitor with an IC50 of 39.2 μM measured in U87MG cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Hedgehog
In Vitro	3-epi-Vitamin D3 (Epicholecalciferol) (5 or 10 μM) significantly upregulates Cyp24A1 in U87MG, HT-29 and C3H10T1/2 cells[1].
References	[1]. Banerjee U, et al. Evaluation of vitamin D3 A-ring analogues as Hedgehog pathway inhibitors. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1330-4.