BioBioPha
China
Product Name: Furanodienone
Price: ￥500.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Furanodienone
Price: ￥1378.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Furanodienone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

24268-41-5

24268-41-5 structure

24268-41-5 structure

Name: Furanodienone
Chemical Name: furanodienone
CAS Number: 24268-41-5
Molecular Formula: C₁₅H₁₈O₂
Molecular Weight: 230.302
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-05-04 08:00:00
Modify Date: 2024-01-02 17:04:53
Furanodienone is one of the major bioactive constituents derived from Rhizoma Curcumae. Furanodienone induced apoptosis[1].

Name	furanodienone
Synonyms	Furanodienon Cyclodeca[b]furan-4(7H)-one, 8,11-dihydro-3,6,10-trimethyl-, (5Z)- furanodien-6-one (5Z)-3,6,10-Trimethyl-8,11-dihydrocyclodeca[b]furan-4(7H)-one furanodiene-6-one (1(10)E,4E)-8,12-epoxygermacra-1(10),4,7,11-tetraen-6-one (5E,9E)-3,6,10-Trimethyl-8,11-dihydro-7H-cyclodeca[b]furan-4-one

Description	Furanodienone is one of the major bioactive constituents derived from Rhizoma Curcumae. Furanodienone induced apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	Furanodienone (0-573.8 μM; 24 hours) exhibits IC50 values : 56.4 μM (RKO), 73.7 μM (sw480), 251.1 μM (HT-29), 412.5 μM (sw620) and 573.8 μM (LoVo) at 24 hours, while that in 48 h are 51.8 μM (RKO), 44.18 μM (sw480), 168.9 μM (HT-29), 314.2 μM (sw620) and 502.1 μM (LoVo), respectively[1]. Furanodienone (0-150 μM; 24 hours) induces apoptosis and shows increase in caspase-9 and -3 activity has been observed in both cells, whereas a relative minor effect on that of caspase-8 in RKO and HT-29 cells[1]. Furanodienone (0-150 μM; 24 hours) increases the apoptotic rates from 2.34±0.45% to 19.45±2.37% and 27.34±0.79%, in RKO cells at 75 and 150 μM. whereas 12.4±1.08 and 20.64±3.02% apoptosis at the concentration of 75 and 150 μM are observed in HT-29 cells compared with 2.89±0.26%[1]. Western Blot Analysis[1] Cell Line: RKO and HT-29 cells Concentration: 0 μM; 50 μM; 100 μM; 150 μM Incubation Time: 24 hours Result: Increased caspase-9 and -3. Apoptosis Analysis[1] Cell Line: RKO and HT-29 cells Concentration: 0 μM; 75 μM; 150 μM Incubation Time: 24 hours Result: Induced apoptosis of colorectal cells (RKO and HT-29).
References	[1]. Li YW, et al. Furanodienone induces cell cycle arrest and apoptosis by suppressing EGFR/HER2 signaling in HER2-overexpressing human breast cancer cells. Cancer Chemother Pharmacol. 2011 Nov;68(5):1315-23.

Density	1.0±0.1 g/cm3
Boiling Point	363.8±42.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₈O₂
Molecular Weight	230.302
Flash Point	172.0±20.6 °C
Exact Mass	230.130676
PSA	30.21000
LogP	4.76
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.510
Storage condition	2-8℃