62034-73-5
62034-73-5 structure
- Name: 4-(tert-Butyl)-benzhydroxamic Acid
- Chemical Name: 4-tert-butyl-N-hydroxybenzamide
- CAS Number: 62034-73-5
- Molecular Formula: C11H15NO2
- Molecular Weight: 193.24
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2017-10-18 01:10:12
- Modify Date: 2024-01-02 21:06:38
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4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively. 4-(tert-Butyl)-benzhydroxamic Acid reduces the production of the virulence factor pyocyanin in P. aeruginosa with an IC50 of 87.2 μM[1].
| Name | 4-tert-butyl-N-hydroxybenzamide |
|---|---|
| Synonyms | p-tert-butyl benzohydroxamic acid |
| Description | 4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively. 4-(tert-Butyl)-benzhydroxamic Acid reduces the production of the virulence factor pyocyanin in P. aeruginosa with an IC50 of 87.2 μM[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 12.5 μM (PqsR in E. coli), 23.6 μM (PqsR in P. aeruginosa), 87.2 μM (virulence factor pyocyanin)[1] |
| References |
| Molecular Formula | C11H15NO2 |
|---|---|
| Molecular Weight | 193.24 |
| Exact Mass | 193.11000 |
| PSA | 49.33000 |
| LogP | 2.49400 |
|
~78%
62034-73-5 |
| Literature: Dettori, Giovanna; Gaspa, Silvia; Porcheddu, Andrea; De Luca, Lidia Organic and Biomolecular Chemistry, 2014 , vol. 12, # 26 p. 4582 - 4585 |
| Precursor 1 | |
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| DownStream 0 | |