330796-24-2

330796-24-2 structure

Name: Hedgehog-IN-7d
Chemical Name: 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[3-(4-fluorophenyl)-4-oxoquinazolin-2-yl]methyl]urea
CAS Number: 330796-24-2
Molecular Formula: C₂₃H₁₅ClF₄N₄O₂
Molecular Weight: 490.837
Create Date: 2019-01-12 07:34:29
Modify Date: 2024-04-03 10:11:22
Hedgehog-IN-7d is a potent, cell-permeable Hedgehog (Hh) pathway inhibitor that inhibits Gli transcription activity with an IC50 value of 70 nM..

Name	1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[3-(4-fluorophenyl)-4-oxoquinazolin-2-yl]methyl]urea
Synonyms	1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-{[3-(4-fluorophenyl)-4-oxo-3,4-dihydro-2-quinazolinyl]methyl}urea Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]-

Density	1.5±0.1 g/cm3
Molecular Formula	C₂₃H₁₅ClF₄N₄O₂
Molecular Weight	490.837
Exact Mass	490.081970
PSA	79.51000
LogP	5.57
Index of Refraction	1.623

330796-23-1

329-01-1

~96%

330796-24-2

Literature: Curtis, Inc. Patent: US6545005 B1, 2003 ;

330796-23-1

327-78-6

~99%

330796-24-2

Literature: Brunton, Shirley A.; Stibbard, John H. A.; Rubin, Lee L.; Kruse, Lawrence I.; Guicherit, Oivin M.; Boyd, Edward A.; Price, Steven Journal of Medicinal Chemistry, 2008 , vol. 51, # 5 p. 1108 - 1110

Precursor 3
330796-23-1 329-01-1 327-78-6
DownStream 0

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