147388-83-8
147388-83-8 structure
- Name: 3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride
- Chemical Name: ABT-418 hydrochloride
- CAS Number: 147388-83-8
- Molecular Formula: C9H15ClN2O
- Molecular Weight: 202.68100
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
- Create Date: 2016-11-22 10:28:42
- Modify Date: 2025-09-18 08:10:37
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ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease[1][2].
| Name | ABT-418 hydrochloride |
|---|---|
| Synonyms |
3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride
3-methyl-5-[(2S)-1-methylpyrrolidin-2-yl]-1,2-oxazole,hydrochloride |
| Description | ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease[1][2]. |
|---|---|
| Related Catalog | |
| Target |
nAChRs[1][2] |
| In Vivo | ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze[1]. Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment[1]. ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD[2]. ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression[2]. Animal Model: Male SHRs (4–5 weeks old), attention deficit hyperactivity disorder (ADHD) model[2] Dosage: 0.6 mg/kg Administration: Intraperitoneal injection; once daily; for two weeks Result: Effectively improved spatial memory. |
| References |
| Boiling Point | 249.2ºC at 760 mmHg |
|---|---|
| Molecular Formula | C9H15ClN2O |
| Molecular Weight | 202.68100 |
| Flash Point | 104.5ºC |
| Exact Mass | 202.08700 |
| PSA | 29.27000 |
| LogP | 2.48960 |
| Vapour Pressure | 0.0232mmHg at 25°C |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300-H310-H330 |
| Precautionary Statements | P260-P264-P280-P284-P301 + P310-P302 + P350 |
| Hazard Codes | T+ |
| Risk Phrases | R26/27/28 |
| Safety Phrases | S22 |
| RIDADR | UN 2811 6.1/PG 1 |